OBJECTIVES to investigate the rate of positivity for immunoglobulin M anti-Toxoplasma gondii (Toxo-IgM) in newborns with congenital toxoplasmosis, and the age when these antibodies become negative. METHODS patients with congenital toxoplasmosis who started monitoring in a congenital infection clinic between 1998 and 2009 were included. Inclusion criteria were routine maternal or neonatal sero...

HSP90B1 is a gene that codifies heat shock protein 108 (HSP108) that belongs to a group of proteins induced under stress situation, and it has close relation with the nervous system, especially in the retina. Toxoplasma gondii causes ocular toxoplasmosis that has been associated with a late manifestation of the congenital toxoplasmosis although experimental models show that morphological altera...

Congenital toxoplasmosis is a worldwide health problem, and different screening strategies exist. Testing of toxoplasma-specific antibodies in infants identifies congenital toxoplasmosis during the first year of life. However, experience with commercial available immunoassays is limited. The aim of this study was to evaluate both the performance and analytical characteristics of the Liaison dia...

BACKGROUND Control programs have been executed in an attempt to reduce vertical transmission and the severity of congenital infection in regions with a high incidence of toxoplasmosis in pregnant women. We aimed to evaluate whether treatment of pregnant women with spiramycin associated with a lack of monitoring for toxoplasmosis seroconversion affects the prognosis of patients. METHODS We per...

maternal infection with toxoplasma gondii acquired during pregnancy may result in congenital infection of developing fetuses. up to now, decision on informed therapeutic abortion of fetuses suspected of having t. gondii infection in iran has been made based on serological findings in mothers. this might have led to unnecessary abortion of many uninfected children. we evaluated the polymerase ch...

OBJECTIVE To estimate the global burden of congenital toxoplasmosis (CT), which results from infection of pregnant women with Toxoplasma gondii. METHODS The authors systematically searched 9 major databases for published and unpublished sources and established direct contact with the authors of source materials. Searches were country-specific. To be included, studies had to report on the inci...

Introduction: Toxoplasmosis is Zoonoses among humans and animals with cosmopolitan distribution. Acquired form of the disease often has no symptoms or discomfort of swollen lymph nodes and associated Chorioretinitis. The congenital form of the disease from mother to fetus via the placenta is delivered. Congenital infection may cause abortion or damage the central nervous system and eye disorde...

Recent studies from Austria, France and Italy have shown that there is a poor adherence to the screening scheme for maternal Toxoplasma infections in pregnancy demonstrated by the fact that many recommended examinations are missed. This leads to undetected infections and limits our knowledge of incidence of the disease. We discuss the negative consequences of this situation on research on treat...

Background: To evaluate whether the treatment of the pregnant women associated with a lack of monitoring for toxoplasmosis seroconversion affected the prognosis of the patients Methods: Cohort study with 292 newborns at risk for congenital toxoplasmosis, in Goiânia-GO (Brazil), between October 2003 until October 2011. We carried out statistical analysis in order to test the efficacy of maternal...