Toxoplasmosis is a common congenital infection. It does not usually produce recognizable signs of infection at birth so most infected newborns are not detected by routine clinical examination and remain untreated. Infected children without clinical symptoms should nonetheless be identified and treated as early as possible. Serological diagnosis of congenital toxoplasmosis is quite difficult. Th...

Fetal parvovirus B19 infection causes anemia, hydrops, and pregnancy loss but is generally not considered teratogenic. Nevertheless, disturbances of neuronal migration have been described with congenital parvovirus infection. We evaluated a term infant with congenital parvovirus disease and polymicrogyria. We compared this case with four other reports of central nervous system disease after bir...

It is over 50 years since a syndrome of congenital abnormalities following maternal rubella infection was first recognised. Despite the potentially devastating effects of the congenital rubella syndrome, immunisation rates are not optimal and infections in pregnancy still occur. Four cases of rubella infection occurring in pregnancy are presented. Laboratory diagnosis of primary infection and r...

The recent article on ‘‘Hearing loss in congenital Zika virus’’ is very interesting.1 Leal et al. reported an interesting case of sensorineural hearing loss in a case of congenital Zika virus.1 In fact, it is no doubt that Zika virus can induce teratogenic effect and the main pathology is on the fetal neurological system. However, the myth is the exact mechanism underlying the hearing loss in t...

The association between congenital cytomegalovirus (CMV) infection and sensorineural hearing loss (SNHL) was first described almost 50 years ago. Studies over the intervening decades have further described the relationship between congenital CMV infection and SNHL in children. However, congenital CMV infection remains a leading cause of SNHL in children in the United States and the world today....

OBJECTIVE To determine whether congenital cytomegalovirus (CMV) infection is an etiologic factor in the pathogenesis of enlarged vestibular aqueducts (EVA). DESIGN Two different cohort studies. Subjects The study population comprised 19 subjects with a history of congenital CMV infection and sensorineural hearing loss (cohort 1); 39 subjects with nonsyndromic EVA and their unaffected mothers ...