Panniculitis is a rarely reported clinical finding in dermatomyositis. It may precede the other manifestations associated with dermatomyositis by as much as 14 months. In all cases, myositis and panniculitis improve simultaneously during treatment. The present report describes the case of a 30-year-old female patient with clinical and histopathological findings consistent with panniculitis two ...

In questo lavoro viene proposta una estensione del linguaggio datalog [CP97]. datalog è un linguaggio logico basato su datalog, la cui innovazione sostanziale consiste nell’aumento della potenza espressiva, tramite l’introduzione di una semantica basata sulla circoscrizione, un meccanismo deduttivo non monotòno che generalizza l’ipotesi di mondo chiuso. Questo tipo di semantica fornisce interes...

A new diphone database with a full diphone set for each of three levels of vocal effort is presented. A theoretical motivation is given why this kind of database will be useful for emotional speech synthesis. Two hypotheses are verified in perception experiments: (I) The three diphone sets are perceived as belonging to the same speaker; (II) The vocal effort intended during database recordings ...

In a collaborative planning environment in which the agents are autonomous and heterogeneous, it is inevitable that discrepancies in the agents' beliefs result in con#icts during the planning process. In such cases, it is important that the agents engage in collaborative negotiation to resolve the detected con#icts in order to determine what should constitute their shared plan of actions and sh...

OBJECTIVE To investigate the effects of an intradermal injection of oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs on concanavalin A (Con A)-induced hepatitis, an experimental model of immune-mediated hepatitis. METHODS Con A was injected intravenously into Balb/c mice. Twelve hours after Con A challenge, blood and liver samples were obtained. CpG ODN was injected intradermal...

BACKGROUND/AIMS Macrophage inflammatory protein-2 (MIP-2), one of the CXC chemokines, is involved in the recruitment of neutrophils in several tissue injuries. In this study, we investigated the role of MIP-2 in concanavalin A (Con A)-induced liver injury in mice. METHODS Liver injury was induced by intravenous injection of Con A (15 mg/kg) and plasma alanine aminotransferase (ALT), MIP-2 lev...

We studied the interaction between deoxynivalenol (DON)-feeding and a subsequent pre- and post-hepatic immune stimulus with the hypothesis that the liver differently mediates the acute phase reaction (APR) in pigs. Barrows (n = 44) were divided into a DON-(4.59 mg DON/kg feed) and a control-diet group, surgically equipped with permanent catheters pre- (V. portae hepatis) and post-hepatic (V. ju...

El pegvisomant (PEG) fue aprobado por la Agencia Europea del Medicamento en noviembre del 2002 para pacientes con acromegalia persistente tras la cirugía y no controlados con análogos de la somatostatina (SSA). En España se comercializó en el año 2004, por lo que transcurridos más de 10 años parece adecuado reflexionar sobre nuestra experiencia con su uso, revisar los últimos datos sobre su efi...

OBJECTIVE We previously showed that brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) is cardioprotective in a canine model of ischemia-reperfusion. This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection. METHODS In anesthetized open-chest rat...

Heat acclimation (HA) attenuates physiological strain in hot conditions via phenotypic and cellular adaptation. The aim of this study was to determine whether HA reduced physiological strain, and heat shock protein (HSP) 72 and HSP90α mRNA responses in acute normobaric hypoxia. Sixteen male participants completed ten 90-min sessions of isothermic HA (40°C/40% relative humidity) or exercise trai...