نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

2009
Priscila Falagan-Lotsch Marina S. Rodrigues Viviane Esteves Roberto Vieira Luis C. Amendola Dante Pagnoncelli Júlio C. Paixão Claudia V. De Moura Gallo

The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively studied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing...

Journal: :Environmental research 2014
Simona Surdu Edward F Fitzgerald Michael S Bloom Francis P Boscoe David O Carpenter Richard F Haase Eugen Gurzau Peter Rudnai Kvetoslava Koppova Marie Vahter Giovanni Leonardi Walter Goessler Rajiv Kumar Tony Fletcher

X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3) polymorphisms are relatively frequent in Caucasian populations and may have implications in skin cancer modulation. A few studies have evaluated their association with non-melanoma skin cancer (NMSC), but the results are inconsistent. In the current study, we aim to assess the impact of XRCC1 R399Q and XRCC3 T241M polymorphism...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005
Jing Shen Marilie D Gammon Mary Beth Terry Lianwen Wang Qiao Wang Fangfang Zhang Susan L Teitelbaum Sybil M Eng Sharon K Sagiv Mia M Gaudet Alfred I Neugut Regina M Santella

The variability in DNA repair capacity of the general population may depend in part upon common variants in DNA repair genes. X-ray repair cross complementing group 1 (XRCC1) is an important DNA base excision repair gene and exhibits polymorphic variation. Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single...

2014
Tao Bu Li Liu Yong Sun Li Zhao Yang Peng Shudong Zhou Lixia Li Sidong Chen Yanhui Gao

BACKGROUND In the X-ray repair cross-complementing group 1 (XRCC1) gene, a polymorphism, Arg399Gln (rs25487), has been shown to change neoconservative amino acid and thus result in alternation of DNA repair capacity. Numerous studies have investigated the association between Arg399Gln and breast cancer risk in the American population, but yielding inconsistent results. This study aimed to clari...

2015
Ping Xue Lin Gao Sha Xiao Guopei Zhang Mingyang Xiao Qianye Zhang Xiao Zheng Yuan Cai Cuihong Jin Jinghua Yang Shengwen Wu Xiaobo Lu Qing-Yi Wei

OBJECTIVES Individual variations in the capacity of DNA repair machinery to relieve benzene-induced DNA damage may be the key to developing chronic benzene poisoning (CBP), an increasingly prevalent occupational disease in China. ERCC1 (Excision repair cross complementation group 1) is located on chromosome 19q13.2-3 and participates in the crucial steps of Nucleotide Excision Repair (NER); mor...

Journal: :Anticancer research 2011
Haijun Zhang Wenjuan Li Michael J Franklin Arkadiusz Z Dudek

Published data on the association between polymorphisms of the X-ray repair cross-complementing group 1 (XRCC1) gene and skin cancer risk are inconsistent. Hence, we conducted a meta-analysis of three frequently occurring XRCC1 polymorphisms and risk of skin cancer to obtain the most reliable estimate of the association. Odds ratios (ORs) with 95% confidence intervals (CIs) were extracted from ...

Journal: :Genetics and molecular research : GMR 2014
B B Sun J Z Wu Y G Li L J Ma

Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a comprehensive meta-analysis in order to assess t...

2011
Huseyin Saribasak Robert W. Maul Zheng Cao Rhonda L. McClure William Yang Daniel R. McNeill David M. Wilson Patricia J. Gearhart

Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce somatic hypermutation (SHM) and class switch recombination (CSR). To unravel the interp...

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