نتایج جستجو برای: competitive inhibition

تعداد نتایج: 412685  

Journal: : 2022

We examined the effects of two different drugs (cladribine and mitoxantrone), which are frequently used in chemotherapeutic treatment, on human serum paraoxanase1 (PON1) enzyme activity vitro. Chemotherapeutic decreased vitro PON1 activity. Cladribine mitoxantrone inhibition mechanism were not competitive inhibitors. IC50 values for cladribine calculated as 0.077 mM 0.099 mM, respectively, Ki c...

Journal: :iranian biomedical journal 0
مریم شعبانی maryam shabani محسن آنی mohsen ani احمد موحدین ahmad movahedian سید ضیاء الدین صمصام شریعت seyed ziyae aldin samsam shariat

background: myeloperoxidase (mpo), which is abundantly expressed in neutrophils, catalyzes the formation of a number of reactive oxidant species. however, evidence has emerged that mpo-derived oxidants contribute to tissue damage and initiation and propagation of inflammatory diseases, particularly, cardiovascular diseases. therefore, studying the regulatory mechanisms of the enzyme activity is...

Journal: :The Journal of biological chemistry 1986
P F Weller E J Corey K F Austen R A Lewis

Arylsulfatase B, purified to homogeneity from human eosinophils, is a tetrameric enzyme whose activity varied in accordance with the state of association of its monomeric subunits. The rate of dissociation of oligomeric forms was slow relative to the rate of the enzymatic reaction so that the kinetic properties of the enzyme depended on the concentration of the enzyme before assay. For concentr...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2006
Susan C Laws S Yavanhxay Ralph L Cooper J Charles Eldridge

This study was conducted to characterize the estrogen receptor (ER)-binding affinities of 50 chemicals selected from among the high production volume chemicals under the U.S. EPA's (U.S. Environmental Protection Agency's) Toxic Substances Control Act inventory. The chemicals were evaluated using the rat uterine cytosolic (RUC) ER-competitive binding assay, with secondary analysis using Lineweav...

2003
G. S. EADIE

It has been gencrally assumed that the inhibition of cholinesterase by physostigmine and prostigmine is non-competitive. This is implicit in the equation given by Matthes (1) relating the degree of inhibition to the concentration of physost)igmine, for it contains no term for substrate concentration, an omission justified only if the inhibition is non-competitive. However, it should be noted, a...

Journal: :Acta biochimica Polonica 2007
Ali Akbar Saboury Mahdi Alijanianzadeh Hasan Mansoori-Torshizi

Sodium salts of four n-alkyl xanthate compounds, C2H5OCS2Na (I), C3H7OCS2Na (II), C4H9OCS2Na (III), and C6H13OCS2Na (IV) were synthesized and examined for inhibition of both cresolase and catecholase activities of mushroom tyrosinase (MT) in 10 mM sodium phosphate buffer, pH 6.8, at 293 K using UV spectrophotometry. 4-[(4-Methylbenzo)azo]-1,2-benzendiol (MeBACat) and 4-[(4-methylphenyl)azo]-phe...

Journal: :Journal of cell science 1979
M Okuno C J Brokaw

Three clinical patterns of inhibition of MgATP2--activated flagellar motility have been found by measuring the motility of Triton-demembranated sea-urchin spermatozoa beating with their heads attached to a glass surface. Inhibition of beat frequency by the reaction products, ADP and Pi, is competitive with the normal substrate, MgATP2-, and the inhibitory effects are similar to a reduction in M...

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