Neural coding through inhibitory projection pathways remains poorly understood. We analyze the transmission properties of the Purkinje cell (PC) to cerebellar nucleus (CN) pathway in a modeling study using a data set recorded in awake mice containing respiratory rate modulation. We find that inhibitory transmission from tonically active PCs can transmit a behavioral rate code with high fidelity...

Compartmental and aggregated modeling is used to derive low-order (reduced) dynamic models from detailed models of staged processes. In this study, the aggregated modeling method of [Lévine, J., & Rouchon, P. (1991).Quality control of binarydistillationcolumnsvianonlinear aggregatedmodels.Automatica, 27, 463] is revised with the objective of deriving computationally efficient models for real-ti...

Joachim Diederich, Queensland University of Technology (Brisbane), started with a brief introduction to connectionist modeling and parallel machines. Neural network modeling can be done on various levels of abstraction. On a low level of abstraction, a simulator can support the definition and simulation of "compartmental models," chemical synapses, dendritic trees etc., i.e. explicit computatio...

BACKGROUND Individual strategies in pandemic preparedness plans may not reduce the impact of an influenza pandemic. METHODS We searched modeling publications through PubMed and associated references from 1990 to 30 September 2009. Inclusion criteria were modeling papers quantifying the effectiveness of combination strategies, both pharmaceutical and non-pharmaceutical. RESULTS Nineteen mode...

This study was conducted to examine the statistical influence of brain size on cortical, subcortical, and cerebellar compartmental volumes. This brain size influence was especially studied to delineate interactions with Sex and Age. Here, we studied 856 healthy subjects of which 533 are classified as young and 323 as old. Using an automated segmentation procedure cortical (gray and white matter...

In an attempt to understand why different organisms defend against potential antigens differently, the influence of possible interactions between host-related factors and respective antigen repertoires on the complexity of host defense mechanisms was investigated. A compartmental model coupling these two variables was developed and tested. Data analysis suggests that the more complex the organi...

The compartmental model is a basic tool for studying signal propagation in neurons; if the model parameters are adequately redefined, it can also be helpful in the study of electrical or fluid transport in other biological systems. Here we show that the input resistance in different networks that simulate the morphology of neurons is the result of the interplay between the relevant conductances...

Ketorolac, a commonly used anti-inflammatory and analgesic agent, was studied in male wistar rats. The plasma samples were analysed using chiral AGP column with UV detection. The experimental data was analysed for probable fit in the compartmental and non-compartmental models using WinNolin software. The data of (+)-R-Ketorolac and (-)-S-Ketorolac was found to fit into the compartmental as well ...