Cryptococcal meningitis (CM) is caused by an opportunistic encapsulated yeast, Cryptococcus neoformans. Despite recent expansion of antiretroviral treatment (ART) programmes in developing countries, CM remains a major opportunistic infection, and a leading cause of mortality in acquired immune deficiency syndrome (AIDS) patients.1 CM has become the leading cause of community-acquired meningitis...

This article discusses a case of Escherichia coli (E. coli) meningitis resulting in altered mental status patient with multiple pre-existing comorbidities. The highlights the underestimated risk community-acquired gram-negative adults, which can have high mortality rate, particularly elderly patients sepsis and urinary tract infections. Diagnosis E. was confirmed by analyzing cerebrospinal flui...

OBJECTIVE To determine if, in the era after Haemophilus influenzae type b, the cerebrospinal fluid (CSF) white blood cell (WBC) count can be safely used to stratify children suspected of having bacterial meningitis into low- and high-risk groups. DESIGN Retrospective analysis of CSF samples. SETTING Tertiary care pediatric center in Toronto, Ontario, between January 1, 1992, and October 1, ...

Recently, the biased β2-adrenoceptor/β-arrestin pathway was shown to play a pivotal role in crossing of the blood brain barrier by Neisseria meningitidis. We hypothesized that genetic variation in the β2-adrenoceptor gene (ADRB2) may influence susceptibility to bacterial meningitis. In a prospective genetic association study we genotyped 542 patients with CSF culture proven community acquired b...

BACKGROUND Listeria monocytogenes (LM) is currently the third most frequent pathogen of bacterial meningitis in adults. METHODS A prospective study of patients with LM meningitis in a Czech tertiary care hospital, carried out from 1997 to 2012. RESULTS Thirty-one patients were diagnosed with LM meningitis, which was 7% of a total of 440 adult patients with acute bacterial meningitis (ABM) o...

background: the emerge of rapid and accurate detection of meticillin-resistant staphylococcus aureus (mrsa) has been highlighted. objectives: the current study evaluated the prevalence of mec-a gene in biological specimens of various medical wards, in order to determine any possible relationship. patients and methods: using traditional culture methods, 250 isolates were detected. the prevalence...