The Rockefeller University Press $30.00 J. Cell Biol. Vol. 192 No. 2 295–306 www.jcb.org/cgi/doi/10.1083/jcb.201007018 JCB 295 Correspondence to Greg Odorizzi: [email protected] Abbreviations used in this paper: DIC, differential interference contrast; ESCRT, endosomal sorting complex required for transport; ILV, intralumenal vesicle; MIT, microtubule interacting and trafficking; MVB, multi...

In this study we compared the amplitude, latency, and spatial distribution of the mismatch negativity (MMN), elicited by tones deviating in either frequency, intensity, stimulus-onset asynchrony (SOA) or location, and assessed inter- and intra-subject variability. Cross-dimensional comparisons were facilitated by adjusting the magnitude of deviance individually, so that the detection rates were...

Progress in lithography and nanofabrication @E. Di Fabrizio et al., Nature ~London! 401, 895 ~1999!# has made it possible to apply differential interference contrast ~DIC! in x-ray microscopy using an original x-ray doublet lens based on two specially developed zone plates. Switching from bright-field imaging ~absorption contrast! to x-ray DIC, we observe, similar to visible-light microscopy, a...

Three c ase studies are used to illustrate some issues which arise when digital image analysis methods are applied in microscopy. An algorithm is described for estimating the diameters of cashmere bres from out-of-focus images. The process of image formation in diierential interference c ontrast DIC microscopy is modelled, and used t o c onstruct templates for identifying and measuring algal, b...

OBJECTIVES The Positive Deviance/Hearth approach aims to rehabilitate malnourished children using practices from mothers in the community who have well-nourished children despite living in poverty. This study assesses its effectiveness in a range of settings. METHODS Systematic review of peer reviewed intervention trials and grey literature evaluation reports of child malnutrition programs us...

OBJECTIVE To describe the application of positive deviance as a strategy to prevent and control bloodstream infections. METHOD An intervention study with nursing and medical team members working in an intensive care unit in a university hospital, between June and December 2014. The four steps of the positive defiance methodology were applied: to define, to determine, to discover and to design...

Purpose Fashion retail employees sometimes “bend the rules” to help their customers. Referred as customer-oriented deviance, this study responds calls examine motivational antecedents of behavior. This research also tests moderating effect tenure on relationships between a frontline employee's motivations, deviance behaviors and commitment organization. Design/methodology/approach Data were col...

Quantitative proteomic profiling using liquid chromatography-mass spectrometry is emerging as an important tool for biomarker discovery, prompting development of algorithms for high-throughput peptide feature detection in complex samples. However, neither annotated standard data sets nor quality control metrics currently exist for assessing the validity of feature detection algorithms. We propo...

The purpose of this study was to address two methodological issues that have called into question whether previously reported gene-environment interaction (GxE) effects for adolescent alcohol use are 'real'. These issues are (1) the potential correlation between the environmental moderator and the outcome across twins and (2) non-linear transformations of the behavioral outcome. Three environme...

High resolution atomic force microscopy (AFM) can be performed simultaneously with optical microscopy techniques, such as fluorescence or differential interference contrast (DIC) microscopy. The combined methodologies provide complementary information about the studied sample which establishes the basis for a better understanding of physiological processes and the function of biomolecules, and ...