BACKGROUND Hyperplastic polyps are common benign colorectal polyps, and are thought to have little association with malignant tumours in the colorectum. However, several reports suggest that some hyperplastic polyps may develop into colorectal neoplasms. AIM To clarify genetic alterations in colorectal hyperplastic polyps. METHODS Twenty eight colorectal polyps having serrated components we...

BACKGROUND Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard. OBJECTIVE To evaluate the frequency and characteristics of colorectal neoplasms that are missed prospectively on OC by using virtual colonoscopy (VC) as a separate reference standard. DESIGN Prospective, multicenter screening trial. SETTING 3 me...

BACKGROUND We performed a laboratory and clinical evaluation of Kroma iT (Linear Chemicals S.L), an immunoturbidimetric analyzer for the detection of fecal occult blood. MATERIALS AND METHODS After a familiarization period, the imprecision, linearity of dilution and carry-over were determined and a clinical evaluation was performed on 210 patients. RESULTS Within-run imprecision ranged betw...

BACKGROUND Although malignant colorectal neoplasms are found more frequently in older population, polyps found at one-time colonoscopy may be a mixture of lesions that developed at various earlier ages. Newly developed adenomas found at the follow-up colonoscopies will reflect the exact relation between malignant potential and the age of development of colorectal polyps. METHODS The results o...

All benign polyps in a 10-year series of 960 patients with colorectal carcinoma from a defined population were analysed. All cases where histological specimens of the polyps were available were reclassified according to morphological type and grade of differentiation. The findings lend support to the assumption of a relationship between benign epithelial neoplasms and adenocarcinoma of the colo...

BACKGROUND AND STUDY AIMS Although endoscopic resection is widely used for the treatment of superficial colorectal neoplasms, the rate of local recurrence of lesions with a positive or indeterminate lateral margin on histologic evaluation is unclear. We aimed to demonstrate the relationship between lateral margin status and local recurrence after the endoscopic resection of intramucosal colorec...

Little is known about the immunoediting process in precancerous lesions. We explored this aspect of benign colorectal adenomas with a descriptive analysis of the immune pathways and immune cells whose regulation is linked to the morphology and size of these lesions. Two series of polypoid and nonpolypoid colorectal adenomas were used in this study: 1) 84 samples (42 lesions, each with matched s...