Foods naturally high in dietary fiber are generally considered to protect against development of colorectal cancer (CRC). However, the intrinsic effect of dietary fiber on intestinal carcinogenesis is unclear. We used azoxymethane (AOM) treated A/J Min/+ mice, which developed a significantly higher tumor load in the colon than in the small intestine, to compare the effects of dietary inulin (IN...

Rijnierse, Anneke, Andries S. Koster, Frans P. Nijkamp, and Aletta D. Kraneveld. TNFis crucial for the development of mast cell-dependent colitis in mice. Am J Physiol Gastrointest Liver Physiol 291: G969–G976, 2006. First published June 22, 2006; doi:10.1152/ajpgi.00146.2006.—Inflammatory bowel disease (IBD) describes chronic inflammatory conditions of the gastrointestinal tract, and TNFplays ...

The octapeptide NAP has been shown to exert neuroprotective properties and reduce neuro-inflammatory responses. The aim of the present study was to investigate if NAP provides anti-inflammatory effects in acute murine colitis. To address this, C57BL/6 j mice were challenged with 3.5% dextran sulfate sodium from day 0 until day 6 to induce colitis, either treated intraperitoneally with NAP or pl...

Geboes, Karen P., Vicky De Preter, Anja Luypaerts, Bert Bammens, Pieter Evenepoel, Yvo Ghoos, Paul Rutgeerts, and Kristin Verbeke. Validation of lactose[N,N]ureide as a tool to study colonic nitrogen metabolism. Am J Physiol Gastrointest Liver Physiol 288: G994–G999, 2005. First published December 30, 2004; doi:10.1152/ajpgi.00408.2004.—In vitro experiments have shown that fermentation of carbo...

Corleto, Vito D., H. Christian Weber, and Robert T. Jensen. Expression of somatostatin receptor subtypes on guinea pig gastric and colonic smooth muscle cells. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G235–G244, 1999.—In vivo and in vitro studies have demonstrated that somatostatin can influence motility and smooth muscle contractility of the stomach and colon. Recent studies have...

Background/Aims After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference of regional colonic transit according to the presence or absence of evacuation disorders, and (3) association of colonic transit with gender in patients with objective...

Somatic changes in CpG dinucleotide methylation occur quite commonly in human cancer cell DNA. Relative to DNA from normal human colonic cells, DNA from human colorectal cancer cells typically displays regional CpG dinucleotide hypermethylation amid global CpG dinucleotide hypomethylation. The role of the maintenance DNA methyltransferase (DNMT1) in the acquisition of such abnormal CpG dinucleo...

Min is a fully penetrant dominant mutation that leads to the development of multiple intestinal adenomas throughout the duodenal-to-colonic axis. Min/+ C57BL6/J mice have an average life-span of 120 d. Multi-label immunocytochemical studies of these lesions demonstrate patches of differentiated enterocytes, and scattered enteroendocrine, goblet and Paneth cells. Expression of endogenous marker ...