cancer is one of the most fatal diseases in human beings which annually leads to death of 30000 individuals in iran. prevention, diagnosis and treatment of cancer is one of the major scientific challenges all around the world. it seems that increased incidence of several cancers such as colon and prostate and their mortality are connected with obesity. it is suggested that obesity and metabolic...

Epithelial cells lining the adult human colon do not normally express gastrin-releasing peptide (GRP) or its receptor (GRPR). In contrast, approximately one-third of human colon cancers and cancer cell lines have been shown to express GRP-binding sites. Because GRPR activation causes the proliferation of many cancer cell lines, GRP has been presumed to act as a clinically significant growth fac...

Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus providing insight into their heterogeneity. CRC patients (n=399) were evaluate...

The registry of digestive tract tumours established for the department of Cote d'Or (France) was used to study the epidemiological characteristics of large bowel cancer subsites for the period 1976-1983. Age standardised incidence rates for colon cancers were 18.9/100,000 for men and 14.2/100,000 for women. The corresponding rates for rectal cancers were 18.4/100,000 and 10.2/100,000. The sex r...

The Wnt/beta-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of beta-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which beta-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Dro...

We tested Tankyrase-1 mRNA expression in colon cancer patients to evaluate the prognostic role of this parameter by real-time RT-PCR in a retrospective group of 82 unselected patients with colon cancer. Paired cancer and corresponding not affected tissues were used. Laser-assisted microdissection was used to measure Tankyrase-1 mRNA in homogeneous cancer cell populations and in normal colon epi...

Twenty mucin genes have been identified and classified in two groups (encoding secreted membrane-bound proteins). Secreted mucins participate mucus formation by assembling a 3-dimensional network via oligomerization, whereas are anchored to the outer membrane mediating extracellular interactions cell signaling. Both associated with carcinogenesis progression epithelial cancers, therefore consid...

Klotho is a transmembrane protein which deficiency has pleiotropic effects in number of aging-related disease processes and various cancers. In some recent studies about klotho disorders, it been shown to effective cancers including lung, liver, breast, kidney, colon. TNF-related apoptosis-inducing ligand (TRAIL), TNF family molecule, cytokine that stimulates apoptosis through death receptors m...

RK Colonoscopy is considered to be the gold standard of colon cancer screening. In fact, colonoscopy has been shown to reduce colon cancer mortality by approximately 50%. However, colonoscopy is not as effective on the right side of the colon as it is on the left side of the colon. Flat and serrated adenomas (precancerous conditions) are more common on the right side of the colon and harbor an ...