A mapping $f\colon X\to Y$ between metric spaces is termed little Lipschitz if the function ${\rm lip}\, f\colon [0,\infty ]$, $${\rm f(x)=\liminf_{r\to 0}\frac{{\rm diam}\,f(B(x,r))}{r},$$ finite at every point. We prove that for

conclusions traf6 plays an important role in the onset of colon cancer; therefore, drugs targeting it may have great clinical significance in the treatment of this disease. results the positive expression rate of traf6 in tumor tissues was 66.7%, which was significantly higher than in normal paracancerous tissues (18.5%). the positive expression rate of traf6 was significantly correlated with d...

aim : to induce acute colitis progresses to chronicity in c57bl/6 mice by dextran sulfate sodium.   background : murine models are essential tools to understand ibd pathogenesis. among different types of chemically induced colitis models, the dextran sulfate sodium (dss)-induced colitis model is the most common model of ibd, due to its simplicity. patients and methods : male c57bl/6 mice 6–8 we...

spontaneous perforation of the sigmoid colon or rectom is defined as a sudden perforation of the colon in the absence of diseases such as tumors, diverticulosis or external injury. it is a very rare finding, and if neglected, results in severe peritonitis and high mortality. the causes of this rare condition are numerous, and in this case it might be due to the chronic constipation induced by a...

a multiple colorimetric assay has been introduced to evaluate the proliferation and determination of survival fraction (sf) of irradiated cells. the estimation of sf based on the cell‑growth curve information is the major advantage of this assay. in this study, the utility of multiple‑mts assay for the sf estimation of irradiated ht‑29 colon cancer cells, which were plated before irradiation, w...

Background: Solid tumors may occur in 3% of the patients with chronic myeloid leukemia (CML). In this paper, we presented a case of CML following treatment of colon cancer. Case Presentation: A 25 year old man was diagnosed of adenocarcinoma of rectosigmoid treated with fluorouracil-based chemotherapy. Following relapse, he received florouracil, oxaliplatin and irinotecan during the next year. ...

Objective(s): This study is aimed to design and synthesize a prodrug of 5-aminosalicylic acid and evaluate its ameliorative effect on experimental ulcerative colitis (UC).Materials and Methods: 5-Aminosalicylic acid-alanine (5-ASA-ALA) was synthesized and characterized. Its stability study was conducted in rat plasma and in the gastroint...

Objective(s): Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-cancer effects of EcN treatments in human colorec...

Introduction: We report a case of a 64-year old man with a history of colon carcinoma. He underwent fine-needle aspiration by CytoFoam-core and diagnosis of metastatic colon cancer to the thyroid gland. Case presentation: In this case report, a solid thyroid nodule in the right lobe of a 64-year-old male was aspirated. The cytological smears showed a small group of atypical cells with the obvi...