نتایج جستجو برای: collagen type i

تعداد نتایج: 2253406  

Journal: :The Journal of Cell Biology 1990
E C Tsilibary L A Reger A M Vogel G G Koliakos S S Anderson A S Charonis J N Alegre L T Furcht

We have previously identified three distinctive amino acid sequences from type IV collagen which specifically bound to heparin and also inhibited the binding of heparin to intact type IV collagen. One of these chemically synthesized domains, peptide Hep-I, has the sequence TAGSCLRKFSTM and originates from the a1(noncollagenous [NC1]) chain of type IV collagen (Koliakos, G. G., K. K. Koliakos, L...

Journal: :Investigative ophthalmology & visual science 1996
E P Kay X Gu S H Choi Y Ninomiya

PURPOSE Type I collagen synthesis in corneal endothelial cells does not correlate with steady state collagen RNA levels; although substantial amounts of alpha 2(I) collagen RNA are present in these cells, type I collagen is not detected. This allowed the authors to investigate the possibility of posttranscriptional control of type I collagen in corneal endothelial cells. METHODS The alpha 2(I...

Hamid Agha-Alinejad, Maghsoud Peeri, Mania Roozbayani, Mohammad Ali Azarbayjani,

Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats. Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were stu...

Journal: :Journal of cellular biochemistry 2003
Kenneth R Cutroneo

In response to tissue injury connective tissue synthesis occurs either normally or abnormally, which is mediated by transforming growth factor-beta (TGF-beta) and other growth factors. This article will be primarily concerned with the response of injured tissues at the gene level of Type I procollagen synthesis in response to TGF-beta. This leads to provisional repair, which in turn may lead to...

Journal: :The Biochemical journal 1991
P Kern M Menasche L Robert

The biosynthesis of type I, type V and type VI collagens was studied by incubation of calf corneas in vitro with [3H]proline as a marker. Pepsin-solubilized collagen types were isolated by salt fractionation and quantified by SDS/PAGE. Expressed as proportions of the total hydroxyproline solubilized, corneal stroma comprised 75% type I, 8% type V and 17% type VI collagen. The rates of [3H]proli...

Journal: :Physiological research 2009
L HLAVACKOVA P JANEGA A CERNA O PECHANOVA R ANDRIANTSITOHAINA P BABAL

Increased amount of collagen type I and decreased amount of type III is described in various pathological processes in the vascular wall. Polyphenols were shown to have protective effect on endothelium, decrease blood pressure and prevent oxidative damage induced by various stimuli. Tetrachlormethane (CCl(4)) is a toxic substance with known negative systemic effects induced by free radicals. Ch...

Journal: :Journal of medical genetics 1985
F M Pope A C Nicholls J McPheat P Talmud R Owen

Type I collagen is a heteropolymer of alpha 1(I) and alpha 2(I) chains, each of which is a separate product of genes localised to chromosomes 17 and 7 respectively. Molecular defects of type I collagen produce a group of inherited disorders of connective tissue primarily affecting bones, which are easily broken and collagen depleted (osteogenesis imperfecta). Sillence classifies these diseases ...

Journal: :Journal of medical genetics 2000
L Nuytinck T Tükel H Kayserili M Y Apak A De Paepe

We report a unique glycine substitution in type I collagen and highlight the clinical and biochemical consequences. The proband is a 9 year old Turkish boy with severely deforming osteogenesis imperfecta (OI). Biochemical analysis of (pro) collagen type I from a skin fibroblast culture showed both normal and overmodified alpha chains. Molecular analysis showed a G>T transversion in the COL1A2 g...

Journal: :Journal of dental research 1995
M Y Kuo H M Chen L J Hahn C C Hsieh C P Chiang

To investigate the mechanism of collagen accumulation in oral submucous fibrosis (OSF) tissues, we examined the biosynthesis of collagen in fibroblast cultures established from OSF lesions. Fibroblasts obtained from four of ten OSF specimens showed more than a 1.5-fold increase in the production of collagens compared with fibroblasts from age-, sex-, and passage-matched normal controls (p < 0.0...

Journal: :The American journal of pathology 2011
Zengxuan Nong Caroline O'Neil Ming Lei Robert Gros Alanna Watson Amin Rizkalla Kibret Mequanint Shaohua Li Matthew J Frontini Qingping Feng J Geoffrey Pickering

Efficient deposition of type I collagen is fundamental to healing after myocardial infarction. Whether there is also a role for cleavage of type I collagen in infarct healing is unknown. To test this, we undertook coronary artery occlusion in mice with a targeted mutation (Col1a1(r/r)) that yields collagenase-resistant type I collagen. Eleven days after infarction, Col1a1(r/r) mice had a lower ...

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