BACKGROUND Gloriosa superba produces an array of alkaloids including colchicine, a compound of interest in the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which has shown anti-gout, anti-inflammatory, and anti-tumor activity. However, this promising compound remains expensive and Gloriosa superba is such a good source in global scale. Increase in ...

Systemic drugs are used in the treatment of several skin diseases. In order to obtain best therapeutic results and prevent side effects, the patients should be carefully screened before and thoroughly evaluated during treatment. In this article guidelines for selection and follow up of patients receiving systemic drugs for their skin diseases are presented. These drugs include azathioprine, ant...

About a quarter of familial Mediterranean fever (FMF) patients have recurrent painful attacks of polyserositis despite regular colchicine treatment. There is no known alternative drug for colchicine-resistant cases. We had previously observed a patient with FMF whose painful attacks disappeared during the 6 month period of interferon alpha (IFN) treatment for his chronic hepatitis B. The object...

Seed treatment with aqueous colchicine solution was carried out for induction of autotetraploidy in ashwagandha in four accessions (Shilpa, Acc. 17, Bydyanath and MWS-327). Increased stomatal size and decrease in stomata density aided in detection of autotetraploids. Among four ashwagandha accessions tried, Acc. 17 was more responsive for the induction of autotetraploids. Colchicine at 0.5 per ...

INTRODUCTION Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial confusion among clinicians. Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a ...

Clerodendrum inerme is a widely used medicinal plant in tropical and subtropical regions of the world. The present study aimed to analyze micronuclei (MN) polyploid (PP) cell-inducing potentials leaf aqueous extract C. (LAECI) Allium cepa root tip cells compared with colchicine induced MN PP A. cells. LAECI increased frequency at 4 h treatment followed by 32 water recovery effects were found be...

this study involves in vitro androgenesis of zea maysl. via anther culture. combination of two embryoinduction media (imss & ypm) in presence of different colchicine concentrations (0, 100, 200, 250, 300and 400 mg/l ) in the pretreatment medium (iml) andpretreatment duration (0, 3, 6 and 9 days) in twogenotypes (dh5×dh7 and eth-m82) were tested.after colchicine pretreatment, anthers were tr...

Miscanthus × giganteus is a popular industrial plant with great potential in ecological agriculture. It forms numerous rhizomes that are important the sequestration of carbon dioxide. The can be source lignin and cellulose, biomass for renewable energy production, used small garden architecture, or to strengthen banks landslides. Breeding this species difficult, as it sterile allotriploid 57 ch...

Colchicine binding and pyrene excimer fluorescence of tubulin have been used to identify cysteine residue(s) essential for the colchicine binding activity of the protein. We report here that both the colchicine binding activity and the ability to form pyrene excimers of tubulin decay at an identical rate when the protein ages at 37 degrees C. Glycerol, which stabilizes the colchicine binding si...

Colchicine is an alkaloid that is used clinically in the treatment of arthritic gout. This potent microtubule disrupting agent has also been used extensively as an experimental tool in studies characterizing the role of the cytoskeleton in a variety of cellular processes. Colchicine has also been used as a selective neurotoxin and in animal models of Alzheimer's disease and epilepsy. Although t...