نتایج جستجو برای: cognitive enhancers
تعداد نتایج: 255486 فیلتر نتایج به سال:
Function and evolution of tele-enhancers ABSTRACT We investigated discriminating features between enhancers separated from their target genes by at least one intermediate gene/exon (named tele-enhancers in this study) and enhancers residing inside the target gene locus. In this study, we used genome-scale enhancer maps and whole-genome gene expression profiles to establish a large panel of hear...
Attempts to improve cognitive function in patients with brain disorders have become the focus of intensive research efforts. A recent emerging trend is the use of so-called cognitive enhancers by healthy individuals. Here, we consider some of the effects - positive and negative - that current drugs have in neurological conditions and healthy people. We conclude that, to date, experimental and c...
SCHIZOPHRENIA, DEPRESSION AND ADDICTION: PROSPECTS AND PITFALLS Professor Trevor Robbins (Cambridge University, U.K.) gave the opening lecture of the meeting and set the scene for the current level of understanding in the field of cognitive enhancement, in particular highlighting opportunities for the future.1 The importance of identifying agents to improve cognition was reinforced by a list of...
The antisaccade task is a measure of volitional control of behavior sensitive to fronto-striatal dysfunction. Here we outline important issues concerning antisaccade methodology, consider recent evidence of the cognitive processes and neural mechanisms involved in task performance, and review how the task has been applied to study psychopathology. We conclude that the task yields reliable and s...
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic islets. Integrated analysis of islet data with those from nine cell types identified specific and significant enri...
Studies of regulatory activity and gene expression have revealed an intriguing dichotomy: There is substantial turnover in the regulatory activity of orthologous sequences between species; however, the expression level of orthologous genes is largely conserved. Understanding how distal regulatory elements, for example, enhancers, evolve and function is critical, as alterations in gene expressio...
Multiple studies have found that increasing histone acetylation by means of deacetylase inhibitor (HDACi) treatment can ameliorate memory and rescue cognitive impairments, but their mode action is not fully understood. In particular, it unclear how HDACis, applied systemically devoid genomic target selectivity, would specifically improve memory-related molecular processes. One theory for such s...
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