Introduction: This study aimed to show the potency of curcumin as an antiapoptotic agent that decreases the apoptotic index in the cochlea lateral wall in ototoxic rat models.   Materials and Methods: A total of 24 Rattus norvegicus were divided into eight groups: Group 1 (control group), Group 2 (gentamicin (+)), Group 3 (gentamicin + curcumin 20 mg/day), Group 4 (gentamicin + curcumin 40 ...

In traditional cochlear implant surgery, physical trauma may occur during electrode array insertion. Magnetic guidance of the has been proposed to mitigate this medical complication. After insertion, guiding magnet attached tip must be detached via a heating process and removed. This may, however, cause thermal within cochlea. study, validated three-dimensional finite element heat transfer mode...

Cochlear frequency selectivity plays a key role in our ability to understand speech, and is widely believed to be associated with cochlear amplification. However, genetic studies targeting the tectorial membrane (TM) have demonstrated both sharper and broader tuning with no obvious changes in hair bundle or somatic motility mechanisms. For example, cochlear tuning of Tectb(-/-) mice is signific...

We have performed a longitudinal study of the content of the putative neurotransmitter substances, enkephalin, dynorphin, and acetylcholine (ACh), in the cochlea of the Fischer 344 rat. It is the first study of transmitters in the rat cochlea over an extended time span. This study also provides biochemical verification of the presence of ACh in cochlear tissues. No change was seen in the cochle...

The height, width and cross-sectional area of the bullfrog amphibian papilla tectorial membrane were quantitatively analysed from frontal serial sections. The cross-sectional area (which is a measure of mass) of the tectorium does not appear to be linearly graded along the length of the papilla, but rather spatial gradations occur in more or less a step-wise manner. The spatially graded area (o...