There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP). In order to assess the role of genetic factors in this mechanism, we studied the association between tumor necrosis factor-α308 (TNF-α308) and myelin basic protein (MBP) 5'-side tetranucleotide repetitive sequence (TGGA) n gene polymo...

conclusions in patients without clear signs of myocardial infarction, even mild co poisoning was associated with quantifiable circulating levels of hs-ctnt when tnt was measured using a highly sensitive assay in the current study patients. plasma levels of the hs-tnt and ck-mb assays were not correlated with the cohb levels in the current study patients. results the mean age of the patients was...

BACKGROUND Carbon monoxide (CO) poisoning can be fatal but is preventable. From October 2010 to February 2011, Anshan Prefecture reported 57 cases of non-occupational CO poisoning in District A, with two deaths. We conducted an investigation to identify risk factors and recommend preventive measures. METHODS We defined a possible case of non-occupational CO poisoning as onset of at least two ...

The increasing demand for organ allografts to treat end-stage organ failure has driven changes in traditional donor criteria. Patients who have succumbed to carbon monoxide (CO) poisoning, a common cause of toxicological mortality, are usually rejected as organ donors. To fulfill the increasing demand, selection criteria must be expanded to include CO-poisoned donors. However, the use of allogr...

Editor—We agree with Hawton et al that co-proxamol presents a major overdose hazard, their results illustrating the difficulties for licensing authorities in limiting availability of prescription medicines that are only hazardous in overdose. Co-proxamol is more likely to result in death; it causes prolongation of the QRS interval in an electrocardiogram in experimental animals and in humans. 3...

OBJECTIVES Erythropoietin has been shown to exert neuroprotective effects in a variety of CNS injury models. Elevation of serum S100β, as a glial damage marker and myelin basic protein (MBP) has been reported to occur in acute carbon monoxide (CO) poisoning. The aim of this study was to evaluate the effect of erythropoietin (EPO) on serum S100β and MBP levels after CO poisoning in rats. MATER...

A case of digoxin poisoning following the co-administration of digoxin and clarithromycin in a 28 year old male is described. Since the aetiology of chronic digoxin poisoning is often unclear, clinicians should be aware of the potential drug-drug interaction between digoxin and clarithromycin.

Carbon monoxide (CO) is the most common toxic gas. It is odourless, colourless, inflammable, and highly toxic. CO is released during incomplete combustion of carboncontaining substances. This gas is the most frequent cause of death by accidental poisoning, as well as being responsible for a significant percentage of suicides. Prevalence of death by CO poisoning increases during the winter due t...

Bachground: Acute carbon monoxide poisoning (COP) is a common problem that occurs more frequently during winter and leads to serious complications. In our Poisoning Referral Center, the incidence and complications of acute COP has not been evaluated previously. Therefore we designed a study to evaluate its significance in our center. Methods & Materials: 111 cases of acute COP admitted duri...

OBJECTIVE To assess the effect of the UK Committee on Safety of Medicines' announcement in January 2005 of withdrawal of co-proxamol on analgesic prescribing and poisoning mortality. DESIGN Interrupted time series analysis for 1998-2007. SETTING England and Wales. DATA SOURCES Prescribing data from the prescription statistics department of the Information Centre for Health and Social Care...