INTRODUCTION Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xanthogranuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with xanthogranulomatous extra skeletal organ involvement. In ECD, central nervous system (CNS) and orbital lesions are frequent, and more than half of ECD pa tients carry th...

hematology- oncology and stem cell transplantation research center related to tehran university of medical sciences located in shariati hospital. these center activities have started in 1991 in order to help needful patients and augment new data to reach new aspects of therapeutic trials. also it is one of the greatest stem cell transplantation centers in world and is the second center in the w...

Abstract Despite the significant progress made in multi-modal treatment of childhood malignancies over last four decades with a concomitantly increased cure rates, benefit is still largely limited to patients leukemias, lymphomas and localized non-CNS solid tumors, leaving high-risk tumours most CNS minimal advancements. More research critical understand what drives these cancers investigate be...

Abstract BACKGROUND: Cranial radiotherapy (RT) is used to treat pediatric central nervous system (CNS) cancers and leukemias. RT carries a risk of secondary CNS malignancies, including radiation-induced gliomas, the epidemiology which poorly understood. METHODS: This retrospective study using SEER registry data (1975-2016) included two cohorts. Cohort 1 patients diagnosed with Grade III/IV or u...

Abstract Tumor associated microglia and macrophages (TAMs) represent a main cell type of brain malignancies demonstrate complex interactions with cancerous cells the tumor microenvironment. These have important implications for progression treatment malignant central nervous system (CNS) tumors. In non-oncological context, it has been shown that endogenous can be replaced by peripheral hematopo...

BACKGROUND Visceral leishmaniasis (VL) caused by Leishmania infantum became a disease of urban areas in Brazil in the last 30 years and there has been an increase in asymptomatic L. infantum infection with these areas. METHODOLOGY/PRINCIPAL FINDINGS A retrospective study of human VL was performed in the state of Rio Grande do Norte, Brazil, for the period of 1990-2014. The data were divided i...

OBJECTIVE To investigate the characteristics of sexual behavior in school-aged adolescents and possible differences regarding sex and type of school. METHODS Cross-sectional study using data from the National Adolescent School-based Health Survey (PeNSE) 2009, carried out by the Brazilian Ministry of Health, in partnership with the Brazilian Institute of Geography and Statistics (IBGE). The s...

Purpose: Homing of malignant lymphocytes to the central nervous system (CNS) may play a role in the pathogenesis of CNS lymphoma. In this study, we evaluated the chemokines CXCL12 and CXCL13 in the cerebrospinal fluid (CSF) and serum of patients with CNS lymphoma. Experimental Design: Samples from 30 patients with CNS lymphoma (23 with primary and 7 with secondary CNS lymphoma; all B-cell lymph...

Central Nervous System malignancies often require stereotactic biopsy or biopsy for differential diagnosis, and for tumor staging and grading. Furthermore, stereotactic biopsy can be non-diagnostic or underestimate grading. Hence, there is a compelling need of new diagnostic biomarkers to avoid such invasive procedures. Several biological markers have been proposed, but they can only identify s...

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