genus and is predominately distributed in the tropical region of Asia, the Pacific Islands, and Australia. Taccalonolides, anthocyanins, diarylheptanoids and diarylheptanoid glucosides, steroidal sapogenins and steroidal glycosides such as C-27 steroidal saponins, C-28 sterol glucosides and withanolide glucosides have been isolated from some Tacca species. Tacca plantaginea (HANCE) is a perenni...

plant, the rhizomes of which have been used for the treatment of enteritis and bacillary dysentery in China and Korea. Several flavonol glycosides, lignans, monoterpenes, tannins, and triterpenenes have been isolated as chemical constituents of this plant. A previous bioactivity-guided investigation for the aerial parts of this plant demonstrated that flavonol glycosides possess hepatoprotectiv...

western North America, and its aerial parts have been used as a cough suppressant and a remedy for respiratory disease by America Indians. As chemical constituents of this plant, the presence of triterpenoids, such as ursolic acid and cucurbitan-type triterpenes as inhibitors of Epstein-Barr virus early antigen (EBV-EA) activation were reported. We reported the isolation and characterization of...

We report a high birefringence terphenyl liquid crystal mixture, designated as M3, for infrared phase modulation with special emphasis on mid-wave infrared (MWIR). In addition to high birefringence, M3 exhibits excellent UV stability, modest dielectric anisotropy, and a very broad nematic range. The high birefringence enables a thin cell gap to be used for achieving a 2π phase change while main...

Acrylamide, used in the manufacture of polyacrylamide and grouting agents, is produced during the cooking of foods. Workplace exposure to acrylamide can occur through the dermal and inhalation routes. The objectives of this study were to evaluate the metabolism of acrylamide in humans following oral administration, to compare hemoglobin adduct formation on oral and dermal administration, to mea...

Purpose: Fatty acid synthase (FASN) is overexpressed in human breast carcinoma. Auth Biom Cièn Facu M.D d'On Bioq Barce Rece Gran RD06 T. Pu Colom 10, T dad A Span de la from Clin The natural polyphenol (-)-epigallocatechin-3-gallate blocks in vitro FASN activity and leads to apoptosis in breast cancer cells without any effects on carnitine palmitoyltransferase-1 (CPT-1) activity, and in vivo, ...

This poster details the discovery of several novel cascade reactions enabling the generation of arrays of pharmacologically relevant small molecules. As such, the synthetic routes are high in molecular complexity generating power and operationally friendly producing attractive compounds for inclusion in file enhancement strategies. Compound libraries and core chemotypes have been designed utili...