BACKGROUND Umbilical cord blood (UCB) is believed to be a highly valuable source of hematopoietic stem cells for transplantation. Objective: To investigate the prevalence of active and latent human cytomegalovirus (CMV) infection in UCB donors in Iranian population. METHODS A total of 825 UCB samples was collected under standard procedures and analyzed for the presence of CMV DNAs in buffy co...

Methods 37 patients who underwent orthotopic heart transplantation have been followed for a period of five years. Posttransplantation screening has been performed over the following etiological agents: CMV, hepatitis B virus, hepatitis C virus, Epstein-Barr virus and Toxoplasma gondii. Receptors with criteria for CMV IgG and Toxoplasma IgG antibodies have been accepted. Infectious episodes at 1...

BACKGROUND Human parvovirus B19 (B19V), cytomegalovirus (CMV) and Toxoplasma gondii (T. gondii) may cause intrauterine infections with potentially severe consequences to the fetus. Current serodiagnosis of these infections is based on detection of antibodies most often by EIA and individually for each pathogen. We developed singleplex and multiplex microsphere-based Suspension Immuno Assays (SI...

Findings of polymerase chain reaction (PCR) studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and breast cancer vary, making it difficult to determine whether either, both, or neither virus is causally associated with breast cancer. We investigated CMV and EBV in paired samples of breast cancer and normal breast tissue from 70 women using quantitative PCR. A serum sample from each w...

Objective. The aim of the study is to investigate peculiarities changes in immune status individuals with active and latent forms herpesvirus infections. Herpesvirus infections are an urgent problem modern health care.
 Materials methods. prospective longitudinal cohort included 92 permanent blood donors who were examined twice at 6-month intervals for presence specific IgM IgG antibodies ...

BACKGROUND A prospective single-center study was performed to study infection with lymphotropic herpesviruses (LH) Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpesvirus 6 (HHV-6) in children with cancer. METHODS The group of 186 children was examined for the presence of LH before, during and 2 months after the end of anticancer treatment. Serology of EBV and CMV was monitored ...

BACKGROUND Cytomegalovirus (CMV) is a common cause of congenital infection worldwide and infants with symptomatic congenital CMV (cCMV) infection are at significantly increased risk of developing adverse long-term outcomes. This study aimed to determine the prevalence of cCMV infections in symptomatic infants under 3 weeks in Tehran, IRAN and to evaluate the usefulness of serologic markers in t...

Background & Aims: Maternal infections with parvovirus B19 and cytomegalovirus (CMV) maybe associated with intrauterine fetal death. The aim of this study was to compare frequency of CMV & Parvovirus B19 Infections in intrauterine fetal death (IUFD) and normal pregnancy. Methods: In a case-control study in Afzalipour Hospital during 2006 placental biopsies were collected from 70 cases of IUFD a...

Cytomegalovirus (CMV) is considered to play a role in triggering autoimmune hepatitis (AIH). It is difficult to diagnose autoimmune hepatitis because its presentation can be acute, severe, asymptomatic or chronic. Diagnosis requires multiple findings and exclusions of similar diseases. When excluding, viral etiologies are part of the differential, which in this case is CMV. If a trigger is requ...