Objective: A randomized, open-label, balanced, two-treatment, two-period, two-sequence, single-dose, crossover bioequivalence study comparing Rizatriptan 10 mg Orally Disintegrating Strips (ODS, test) with that of established Oral Lyophilisate mg, Maxalt-MLT® (reference) was conducted in 24 healthy male volunteers under fasting conditions. single oral dose administrated to each volunteer. Metho...

the pharmacokinetic properties of amoxicillin and clavulanic acid when used alone or in combination may be different and show interaction between these two agents that might decrease the absolute bioavailability of clavulanic acid. in an open, randomized, replicated latin square under fasting condition, pharmacokinetics of new formulations of amoxicillin/clavulanic acid were compared with a ref...

328 words Introduction: 420 words Discussion: 1403 words Abbreviations: AUC, area under the curve; CL, clearance, Cmax, maximum concentration; F, bioavailability; Fa, fraction absorbed; Fg, fraction escaping gut wall elimination; Fh, fraction escaping hepatic elimination; HLM, human liver microsomes; PK, pharmacokinetics, SD, standard deviation; tmax, time to reach Cmax. This article has not be...

Fluoxetine drops and marketed fluoxetine capsules had quite the same Cmax (50.25 +/- 4.43 vs 47.55 +/- 5.29 ng/ml), but significantly different AUC0-t (717.27 +/- 71.29 vs 644.91 +/- 78.91 ng/ml/h). Furthermore the drops were characterised by a very early Tmax (4.61 +/- 0.85 hours) with a highly significant difference in comparison to the capsules reference compound (6.72 +/- 1.23 hours). After...

We consider the problem of minimizing the makespan(Cmax) on m identical parallel batch processing machines. The batch processing machine can process up to B jobs simultaneously. The jobs that are processed together form a batch, and all jobs in a batch start and complete at the same time. For a batch of jobs, the processing time of the batch is equal to the largest processing time among the job...

PurposeCelecoxib-tramadol co-crystal (CTC) is a first-in-class of celecoxib and racemic tramadol. This Phase 1 bioavailability study compared single-dose pharmacokinetic (PK) parameters CTC with those the individual reference products from United States, immediate-release tramadol, taken alone simultaneously to determine their systemic exposure.MethodsThis was single-center, randomized, single-...

Triazolam 0.5 mg was administered to 11 dialysis patients and 11 age, weight and sex matched controls. Peak plasma concentrations (Cmax) were higher in control subjects, but there were no other differences between the groups. When dialysis patients took triazolam with 3600 mg aluminum hydroxide suspension, Cmax and AUC were increased into the range observed in control subjects. It appears that ...

Achieving a peak aminoglycoside concentration (Cmax)/MIC of > or = 10 within 48 h of initiation of therapy for pneumonia caused by gram-negative organisms results in a 90% probability of therapeutic response by day 7. Targeting an MIC of 1 microgram/ml, empirical aminoglycoside loading doses of 348 (25th- to 75th-percentile range, 275 to 432) mg were calculated to obtain a Cmax/MIC of 10 in our...

The relative bioavailability of the test (generic) product 2 × 25 mg baclofen tablets, with respect to the reference product, Lioresal® 2 × 25 mg tablets (baclofen; Squibb) was determined in a single-blind, single dose, randomised, crossover study. The mean values for the variable Cmax were 737.6 ng/ml for the reference and 739.5 ng/ml for the test product. The mean values for the variable AUC ...