BACKGROUND & AIMS HCV-related cirrhosis is a leading risk factor for hepatocellular carcinoma (HCC). Surveillance might detect HCC at a treatable stage. We estimated the clinical and economic consequences of a common HCC surveillance strategy in patients with HCV-related cirrhosis in the context of alternative HCC treatment strategies. METHODS With a Markov model, we examined surveillance wit...

BACKGROUND Recurrent implantation failure (RIF) following embryo transfer (ET) is a major continuing problem in IVF. Women with haemostatic defects may be at increased risk of miscarriage and preclinical pregnancy loss. The fibrinolytic system is considered, at present, the key to new thrombotic pathogenic mechanisms. Patients with unexplained recurrent miscarriage have an impairment of fibrino...

introduction: despite the importance of curriculum analysis for internal refinement of a programme, the approach for such a step in under-described in the literature. this article describes the analysis of the medical curriculum at the faculty of medicine, university of gezira (fmug). this analysis is crucial in the era of innovative medical education since introducing new curricula and curricu...

Data on genetic and environmental factors influencing PAI-1 levels and their consequent effect on clot lysis in black African populations are limited. We identified polymorphisms in the promoter area of the PAI-1 gene and determined their influence on PAI-1act levels and plasma clot lysis time (CLT). We also describe gene-environment interactions and the effect of urbanisation. Data from 2010 a...

We explore the relevance of the celebrated Central Limit Theorem (CLT) of statistics to citation averages, namely, Impact Factors (IF). The CLT predicts that, first, due to random fluctuations, the range of IF values that are statistically available to a journal of size n, follows a 1/ √ n behavior. Large journals (high-n), whose IF’s vary within a narrower range, are thus penalized in IF ranki...

Immunoglobulins (Ig) play a key role in protection of fish against bacterial and viral pathogens. Atlantic salmon has three types of Ig (M, D and T), of which IgM is the main actor of the adaptive humoral immunity. Ig heavy chains are encoded with two loci and their variable regions (VR) are produced by somatic recombination of J, D and V genes. While immunological methods detect specific antib...

The general model of coagulation is considered. For basic classes of unbounded coagulation kernels the central limit theorem (CLT) is obtained for the fluctuations around the dynamic law of large numbers (LLN) described by the Smoluchovski equation. A rather precise rate of convergence is given both for LLN and CLT.

BACKGROUND Preventive services and health promotion in terms of lifestyle counselling provided through primary health care (PHC) has the potential to reduce morbidity and mortality in the population. Health professionals in general are positive about and willing to develop a health-promoting and/or preventive role. A number of obstacles hindering PHC staff from addressing lifestyle issues have ...