Hemostasis depends largely on the conversion of fibrinogen to fibrin, catalyzed by the enzyme thrombin. In recent years, there has been considerable advance of knowledge of the formation of thrombin from its various precursors. However, a comparatively small amount of effort has been directed toward studies of the physical nature of the fibrin clot as a possible guide in the better understandin...

Background: Nowadays, the most important aspect of hemodialysis is the technical method of anticoagulation of extracorporeal circuit. This quasi-experimental study was performed to compare three methods of heparinization in the extracorporeal circulation. Methods: Twenty-seven hemodialysis patients referring to Rafsanjan Hemodialysis Center with the weight range of 50-90 kg and normal Clotting ...

BACKGROUND Replacement of fibrinogen is presumably the key step in managing dilutional coagulopathy. We performed an in vitro study hypothesizing that there is a minimal fibrinogen concentration in diluted whole blood above which the rate of clot formation approaches normal. METHODS Blood samples from six healthy volunteers were diluted 1:5 v/v with saline keeping haematocrit at 24% using red...

Following an injury to the walls of a blood vessel, platelet aggregation and blood coagulation are induced. Through a series of enzymatic and biochemical interactions, a blood clot is formed. Using ordinary differential equations with mass action and Michaelis-Menton kinetics to describe these interactions and computer programs like Fortran and Matlab, we are able to model blood clot formation ...

Using laser fluctuation spectroscopy, a technique that measures particle size change in solution, the kinetics of fibrin clot formation from fibrinogen can be studied. With this technique the effect of calcium on the three distinguishable phases of clot formation, (1) proteolysis of fibrinogen, (2) fibrinogen-fibrin monomer complex formation, and (3) fibrin monomer polymerization, were investig...

Dabigatran etexilate is a prescription medication used to slow and inhibit the formation of blood clots. Dabigatran is known by the trade name Pradaxa in the United States and all other countries in which it is marketed except Japan (Prazaxa) and Canada (Pradax). Although forming blood clots is a normal and important body function needed to stop bleeding, for some people the blood clot formatio...

hemorrhagic bowel syndrome is a highly fatal intestinal disease of adult dairy cattle with uncertain cause. in a dairy herd in khorasanrazavi province, northeast of iran, two cows showed depression, anorexia, decrease in milk production, ruminal hypomotility, bruxism and dehydration. at necropsy, massive hemorrhage and clot formation was observed within the jejunum and bacterial culture of the ...