PURPOSE A prospective, multisite clinical study (10 sites in the European Union and the United States) evaluated the clinical utility of commonly used tests and tear osmolarity for assessing dry eye disease severity. METHODS Three hundred fourteen consecutive subjects between the ages of 18 and 82 years were recruited from the general patient population, 299 of which qualified with complete d...

The presumptive diagnosis was made on clinical grounds in the majority of cases, the signs and symptoms being those usually described-redness and discomfort, tenacious mucous discharge, and corneal erosions and filaments. Confirmation was obtained by the measurement of the lacrimal secretion by the filter-paper test (Schirmer, 1903) and in doubtful cases by staining with rose bengal. The relati...

BACKGROUND Diabetes-related eye disease is due in part to oxidative stress. Gamma-glutamyl transpeptidase (GGT) is a γ-glutamyl cycle enzyme that protects against oxidative stress via glutathione recapture. This study investigates corneal and Schirmer tears GGT activity in diabetic and non-diabetic adults aged 50 to 83 years old. METHODS GGT activity was determined by colorimetric assay on 50...

BACKGROUND A deficiency in the tear film lipid layer is aetiological in about 80 % of the patients suffering from dry eye, which results in excessive evaporation (so-called hyperevaporative dry eye). The treatment with conventional artificial tears did not prove to be successful here. In this study the treatment with two tear substitutes containing lipids were set in contrast with each other. ...

purpose: to detect the prevalence of dry eye after vitrectomy and its influencing factors. methods: schirmer i, tear basic secretion test and tear breakup time was done preoperatively and 3 months postoperatively on consecutive patients undergoing vitrectomy in khatam hospital from 2005 to 2006. eyes with previous peritomies of more than 120◦ and symptoms of dry eye or tear tests compatible wit...

Objective: to evaluate in the ocular surface of patients postoperative period a Post-Anesthetic Recovery Unit clinical predictors for dryness nursing diagnosis (ND) Risk dryness. Method: cross-sectional study carried out from May August 2017. Sample consisted 157 patients. Data were analyzed using descriptive and inferential statistics. Results: prevailed 85.35% patients, while ND was present 1...

Introduction “Blink” is defined as closing and opening of the eyes in a small duration of time. In this study, we aimed to introduce a fast, robust, vision-based approach for blink detection. Materials and Methods This approach consists of two steps. In the first step, the subject’s face is localized every second and with the first blink, the system detects the eye’s location and creates an ope...

OBJECTIVE To examine whether women with premature ovarian failure (POF) have abnormal findings in ocular surface or tear parameters and whether they report symptoms of ocular discomfort compared with age-matched controls. METHODS Sixty-five patients with POF and 36 age-matched healthy controls were examined for signs and symptoms of dry eye. The Ocular Surface Disease Index questionnaire and ...

Purpose Pharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders. We previously reported the discovery of aminophenyl-1,3,5-triazines, one of which, N-methyl-N-phenyl-6-(2,2,3,3-tetrafluoropropoxy)-1,3,5-triazine-2,4-diamine (herein called CFTRact-K267), fully activa...

PURPOSE To evaluate by in vivo laser scanning confocal microscopy (LSCM) the morphologic changes in the meibomian glands (MGs) and the status of periglandular inflammation in contact lens wearers (CLWs) and to investigate the correlations between clinical and confocal findings. METHODS Twenty CLWs and 20 age- and sex-matched control subjects were consecutively enrolled. Each participant compl...