The applications of Clonal Selection Algorithms (CSAs) in solving combinatorial problems are frequently faced with a premature convergence problem and the maturation processes are trapped into a local optimum. This premature convergence problem occurs when the population of a clonal selection algorithm reaches a suboptimal state that the immune operators can no longer produce new immune cells w...

Cancers arise from successive rounds of mutation and selection, generating clonal populations that vary in size, mutational content and drug responsiveness. Ascertaining the clonal composition of a tumor is therefore important both for prognosis and therapy. Mutation counts and frequencies resulting from next-generation sequencing (NGS) potentially reflect a tumor's clonal composition; however,...

In this paper, an important class of hypermutation operators are discussed and quantitatively compared with respect to their success rate and computational cost. We use a standard Immune Algorithm (IA), based on the clonal selection principle to investigate the searching capability of the designed hypermutation operators. We computed the parameter surface for each variation operator to predict ...

This paper investigates the use of clonal selection principles based on our immune system for optimization applications in electromagnetics. This concept is based on our immune system’s ability to respond to an antigen and produce a pool of anti-body secreting cells. In addition to the common implementations of this algorithm where the affinity maturation and cloning principles of clonal select...

Artificial immune systems (AIS) constitute a relatively new area of bio-inspired computing. Biological models of the natural immune system, in particular the theories of clonal selection, immune networks and negative selection, have provided the inspiration for AIS algorithms. Moreover, such algorithms have been successfully employed in a wide variety of different application areas. However, de...

To keep the diversity of antibodies in artificial immune system evolution process, this paper puts forward a kind of increase simulation surname inheritance algorithm based on the clonal selection algorithm, and identification and forecast the Vibration Data about CA6140 horizontal lathe machining slender shaft workpiece prone. The results show that the algorithm has the characteristics of flex...