GAWIN, F. H. & MARKOFF, R. A. (1981), Panic anxiety after abrupt discontinuation of amitryptilline. American Journal of Psychiatry, 138, 117-118. KRAFT, T.B. (1977), Ernstige abstinentieverschiznelsen na het gebruik van clomipramine. Nederlandsch Tijdschr Geneesk, 121, 1293. PETTI, T. A. & LAW, W. (1981), Abrupt cessation of high dose imipramine in children. Journal of American Medical Associat...

Study selection Studies were eligible if they were randomised, doubleblind parallel trials of at least 8 weeks duration; used the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) to assess the efficacy of clomipramine or selective serotonin reuptake inhibitors for obsessive-compulsive disorder, and included point estimates, standard deviations or calculable data. The authors included 25 trials.

Trypanothione reductase is a key enzyme in the trypanothione-based redox metabolism of pathogenic trypanosomes. Because this system is absent in humans, being replaced with glutathione and glutathione reductase, it offers a target for selective inhibition. The rational design of potent inhibitors requires accurate structures of enzyme-inhibitor complexes, but this is lacking for trypanothione r...

Series of experiments and clinical trials were conducted to evaluate the effects of psychoneurotropic agents on sexual behaviour of stallions. The benzodiazepine derivative, diazepam (Valium), effectively reversed experimentally suppressed precopulatory arousal and response. Diazepam treatment also blocked the negative effect of novel environment on sexual response. The dibenzazepines imipramin...

Most reports of drug treatment for obsessivecompulsive neurosis concern one tricyclic antidepressant, namely clomipramine. Early suggestions that the drug might be valuable in this condition were based on uncontrolled and/or short-term studies over only a few weeks (Fernandez and Lopez-Ibor, 1967; Beaumont, 1973; Capstick, 1975; Ananth et al., 1978). A recent controlled study with long-term fol...

1], the antidepressant drug desmethylclomipramine has shown an interesting synergistic effect with cisplatin, gemcitabine or placlitax on lung cancer stem cells. The fact that antidepressant drugs potentiate chemotherapy in poorly responding cancer is of major relevance, and opens up potential innovative therapeutic effects. But what are the underlying molecular mechanisms for this therapy? Can...