It is proposed that personality (conceptualized in terms of motives and psychological resources) changes normatively not only from young adulthood to middle age but also within middle age and that these changes take place in relation to social and biosocial change over the same period. Data from 123 women studied at ages 27, 43, 52, and 61 largely supported hypotheses about change in social rol...

BACKGROUND A Vygotskian framework links cognitive change to collaborative interaction with a more competent partner whereas a Piagetian perspective supports the view that cognitive conflict arising from peer interaction leads to cognitive change. AIMS The study investigated the effect of collaborative learning on children's problem-solving ability and whether differences in knowledge status o...

Research on age-related cognitive change traditionally focuses on either development or aging, where development ends with adulthood and aging begins around 55 years. This approach ignores age-related changes during the 35 years in-between, implying that this period is uninformative. Here we investigated face recognition as an ability that may mature late relative to other abilities. Using data...

The objective of our study was to establish whether rectal temperature recordings in humans could be replaced by a non-invasive skin temperature sensor combined with a heat flux sensor (Double Sensor) located at the forehead to monitor core body temperature changes due to circadian rhythms. Rectal and Double Sensor data were collected continuously for 24h in seven men undertaking strict head-do...

OBJECTIVE The current study examined a 5-year cognitive change in untrained African American and White participants from the Advanced Cognitive Training in Independent and Vital Elderly (ACTIVE) study. METHOD Five-year trajectories of memory, reasoning, visual processing speed/useful field of view, digit-symbol substitution, and vocabulary were investigated. Education, health, gender, age, an...

Using three waves of data, we assessed the relationships between endorsement of religious values, some of the major personality dimensions, and social and emotional well-being amongst teenagers. Participants were 784 high school students at Time 1 (382 males and 394 females; 8 did not indicate their gender) and 563 provided data at each of Time 1, Time 2 and Time 3. We examined the impact of ch...

background and objective: the dbc2 (deleted in breast cancer 2) or rhobtb2 (located on 8p21) is a tumor suppressor gene associated with tumorigenesis. mutational studies of dbc2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. epigenetic changes through hypermethylation of the promoter can cause the inactivation of dbc...

PURPOSE This study was designed to detect aberrant p16 promoter methylation in the serum of patients with colorectal cancer (CRC) and to explore the possibility of using this assay in early detection or as a prognostic marker of CRC patients. EXPERIMENTAL DESIGN Methylation-specific PCR was used to detect p16 methylation in DNA extracted from 52 CRCs and matching serum samples and control ser...

Background and Objective: The DBC2 (deleted in breast cancer 2) or RhoBTB2 (Located on 8p21) is a tumor suppressor gene associated with tumorigenesis. Mutational studies of DBC2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. Epigenetic changes through hypermethylation of the promoter can cause the inactivation of DBC...