Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced m...

Chromoblastomycosis is a chronic fungal infection primarily of skin and subcutaneous tissue caused by a variety of dematiaceous fungal species belonging to different genera. We report a case which remains undiagnosed for 15 years although it presented with the most common manifestation. It was diagnosed and treated with excellent clinico-microbiological and histo-pathological correlation.

OBJECTIVES To study the clinico-immunological, nutritional and growth characteristics of HIV-infected children and the impact of antiretroviral therapy (ART) on these parameters. DESIGN Retrospective study. SETTING Out-patient department of a paediatric ART centre, Delhi, India. SUBJECTS HIV-positive children registered at the paediatric ART centre of the hospital were enrolled (n 130). A...

BACKGROUND This study aimed to investigate renal outcomes and their predictors in biopsy-proven hypertensive nephrosclerosis (HN) patients and to compare clinico-pathological characteristics and prognoses between benign nephrosclerosis (BN) and malignant nephrosclerosis (MN) patients. METHODS Data for biopsy-proven HN patients were retrospectively analyzed. Renal survival rates and relationsh...

PURPOSE To correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM) tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort. METHODS Based on chromosomal 3 aberration, UM (n = 86) were grouped into monosomy 3 (M3; n = 51) and disomy 3 (D3; n = 35) by chromogenic in-situ hybridisation (CISH). The clinico-pathological features w...

RhoA protein is over-expressed in breast cancer and other solid tumors and has been used in tumor biopsies as a quantitative tumor marker for progression, stage and prognosis in molecular detection strategies. Measuring protein markers in plasma or blood cells is preferred to tumor biopsies as it represents a minimally invasive, repeatable measurement that can be followed over time. In this stu...

BACKGROUND Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs). Many of the OSCCs present at late stages with an exceptionally poor prognosis. A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis thereby resulting in an inability to deliver...

OBJECTIVES To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and toevaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease. MATERIAL AND METHODS The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a c...

Background: Distinguishing between sub-clinical and aggressive forms of prostate cancer is difficult due to the heterogeneity of the disease. It is, however, important to identify aggressive forms to guide proper treatment. This study compared gene expression profiles in cancer cells from hereditary and sporadic prostate cancer cases and attempted to correlate differentially regulated genes wit...

Objetivo: O objetivo desse relato é descrever um caso raro de sinusite fúngica invasiva crônica que evoluiu com meningite causando síndrome hipertensão craniana e tetraplegia, demonstrando por meio deste, a importância da realização uma investigação diagnóstica mais aprofundada mesmo em doença considerada diagnóstico clinico. Assim, evitar o retardo terapia adequada.