represents the most important advance in clinical oncology in the last decade—not only because of the magnitude of the difference (a more than 40% increase in 5-year survival over that with previously available therapies) 1, but also because of the means by which that increase occurred. In this sense, cml represents a model disease for oncology, with the Philadelphia chromosome being the first ...

The National Clinician Scientist Scheme was devised to enable future leaders of academic medicine to continue post-doctoral research and at the same time complete their specialist registrar training. The awards are generously funded by the major grant-giving bodies and are held in a variety of specialties in academic departments across the UK. Award winners are given the suffix A to add to thei...

Cancer immunotherapy is coming of age. It has become abundantly clear that immunotherapy-which has been described as treating the body's immune system so the immune system can treat the cancer-can be routinely effective, and may indeed cure advanced cancers. Accordingly, it is important to understand the basic, clinically relevant principles of cancer immunology to better prepare for an increas...

authentic picture on the main directions of activities in this field. However, it is the inclusion of the discussions which is most appreciated. These are valuable because they help us to form a more realistic judgment about the hardness of some hard facts and warn us to respect gaps between facts and conclusions, between conclusions and "'generally accepted theories" of the immune response. On...

OBJECTIVE Patients with limited health literacy (LHL) and limited English proficiency (LEP) experience suboptimal communication and health outcomes. Electronic health record implementation in safety net clinics may affect communication with LHL and LEP patients.We investigated the associations between safety net clinician computer use and patient-provider communication for patients with LEP and...

Clinician-scientists are particularly well positioned to bring basic science findings to the patient's bedside; the ultimate objective of basic research in the health sciences. Concerns have recently been raised about the decreasing workforce of clinician-scientists in both the United States of America and in Canada; however, little is known about clinician-scientists elsewhere around the globe...