To improve clinical care practice, it is important to understand the variability of pathways executed in different contexts (e.g., geographical locations, demographics, and phenotypic groups). A common way representing through network-based representations that capture trajectories treatment steps. However, first-order networks, which are based on Markovian property de facto standard model repr...

personalized medicine is a set of diagnostic, prognostic and therapeutic approaches in which medical interventions are carried out based on individual patient characteristics. as life expectancy increases in developed and developing countries, the incidence of diseases such as cancer goes up among people in the community. cancer is a disease that the response to treatment varies from one person...

results like other cancers, prostate cancer is caused by an accumulation of genetic alterations in a cell that drives it to malignant growth. specific genes and gene alterations have been suggested to play a role in its development and progression. aneuploidy, loss of heterozygosity, gene mutations, hypermethylation and inactivation of specific tumour suppressor genes such as gstpi, apc, mdr1, ...

Although many hospitals have implemented clinical pathways to standardize the process of care, the effectiveness of clinical pathways for total hip and knee arthroplasties has not been reviewed critically. We searched for articles comparing outcomes of total hip or knee arthroplasty for patients who were treated using clinical pathways as opposed to patients treated without these pathways. Elev...

BACKGROUND A geriatric hip fracture clinical pathway, led by an orthopedic surgeon, was developed in 2007. This clinical pathway team is multidisciplinary and consists of surgeons, physicians, anesthetists, nurses, physiotherapists, occupational therapists, medical social workers, dieticians as well as voluntary support groups. METHODS From early 2007 onward, all patients older than 65 years ...

The scientific basis of modern clinical practice is founded on the randomised controlled trial [1]. Trials are experimental studies in which two or more selected groups (arms) which may (or may not be) "representative"of the whole population are assigned at random to one or more interventions and sometimes to an inert control (placebo) or compared to standard practice. The idea is that randomis...

Clinical pathways (CPWs) are a common component in the quest to improve the quality of health. CPWs are used to reduce variation, improve quality of care, and maximize the outcomes for specific groups of patients. An ongoing challenge is the operationalization of a definition of CPW in healthcare. This may be attributable to both the differences in definition and a lack of conceptualization in ...

BACKGROUND Although the "open abdomen" has likely contributed to improved outcomes in trauma patients, the challenge of subsequent fascial closure has emerged. Since mid 2004, we have incorporated Wittmann Patch staged abdominal closure into our management of the open abdomen. The purpose of this study was to evaluate the impact of this device on our incidence of fascial closure versus planned ...

Bingham, P., Ashikaga, T. & Abbasi, S. (2010). Prospective study of non-nutritive sucking and feeding skills in premature infants. Archives of Disease in Childhood, Fetal Neonatal Edition, 95(3): F 194-200. Kirk, A., Alder, S. & King, J. (2007). Cue-based oral feeding clinical pathway results in earlier attainment of full oral feeding in premature infants. Journal of Perinatology, 27: 572-578. ...