Background: Autoimmune hepatitis (AIH) in childhood has variable modes of presentation, and the disease should be suspected and excluded in all children presenting with symptoms and signs of prolonged or severe acute liver disease. In AIH, the liver biopsy histopathology shows inflammation in addition to presence of serum autoimmune antibodies and increased levels of immunoglobulin G (IgG). Ob...

conclusions fulminant hepatitis b is associated with distinct mutational patterns of hbv, underlining that genomic diversity of the virus is an important factor determining its pathogenicity. results the most commonly detected diversities affect regulatory motifs of hbv in the core and s region, indicating that these alterations may convert the virus to an aggressive strain. moreover, mutations...

The Basic Act on Hepatitis Countermeasures issued in 2009 states the comprehensive measures that can be taken against viral hepatitis as well as the responsibility that the national government, local governments, health insurance provides, physicians, and citizens should take in these measures, thereby organically facilitating the construction of a hepatitis management system in Japan. In addit...

The emergence of acute, severe non hepA–E hepatitis unknown etiology (ASHUE) has attracted global concern owing to the very young age patients and its etiology. Although this condition been linked several possible causes, including viral infection, drugs and/or toxin exposure, exact cause remains unknown; makes treatment recommendation difficult. In review, we summarize recent updates on clinic...

BACKGROUND Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) population have resulted in acute hepatitis A being recognized as a sexually transmitted disease. However, few studies have clarified the clinical manifestations in these outbreaks invo...

Background and Aims: Chronic hepatitis C is one of the most important etiologies of cirrhosis and hepatocellular carcinoma worldwide. Clinical condition of hepatic patients and the outcome of chemotherapy are under impact of Hepatitis C virus (HCV) genotypes. Therefore, HCV genotyping is important for prediction of success of chemotherapy and progression of liver diseases. Methods: In thi...

Salmonella infection occurs worldwide and is still an important public health problem in many developing countries. The infection can affect almost all major organs including the liver. Severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. In this paper, a 39-year-old male with acute cholestatic typhoid hepatitis is presented. The case had a tender hepato...

Corresponding author: Dr. Oguz Karabay, Department of Clinical Microbiology and Infectious Diseases, Izzet Baysal University School of Medicine, Golkoy, Bolu, Turkey. E-mail: [email protected] Hepatitis B infection is prevalent worldwide and a major health burden due to the associated complications of hepatic fibrosis, cirrhosis and hepatocellular carcinoma that occur in the context of chroni...

Analysis of the self-cleavage of ribozymes derived from the genomic RNA of Hepatitis delta virus (HDV) has revealed that certain co-transcribed vector sequences significantly affect the activity of the ribozyme. Specifically, the t1/2 of self-cleavage for a 135 nucleotide HDV RNA varied, at 42 degrees C, from 5 min to 88 min, depending on the vector-derived sequences flanking the 5' end of the ...

A 3 year old boy who had chronic active hepatitis type B with features of ongoing liver damage and active virus replication, developed acute membranous glomerulonephritis two years after the clinical onset of liver disease, when both hepatitis B e antigen and antibody were detectable in serum. After withdrawal of short term steroid treatment and resolution of hepatitis B virus replication, both...