Editors' Note: This month we continue the new featureSTEPped Care: An Evidence-BasedApproach to Drug Therapy. These articles are designed to provide concise answers to the drog therapy questions that family physicians encounter in their daily practice. The format of the feature will folhw the mnemonic STEP: safety (an analysis of adverse effects that patients and providers care about), tolerabi...

D URING the last few years reports have appeared of the favorable therapeutic effect of anticoagulants oni pain in cases of allgina pectoris. Heparin at first had its advocates, but later the possibility of reducing the severity and frequency of the anginal atta(ks through the use of this drug has )eeii seriously disputed.1 At l)resellt the use of Dicunnarol and allied dlrtigs is collsidered mo...

Reactive species are products of normal cellular metabolism and may be deleterious or beneficial. At low/moderate concentrations, reactive species are involved in physiological roles including cell signalling, defense against infectious agents and mitogenic responses. However, unbalanced defense mechanism of antioxidants, overproduction of reactive species or incorporation of free radicals into...

To create a comprehensive dataset of peripheral dose (PD) measurements from a new generation of linear accelerators with and without the presence of a newly designed fetal shield, PD measurements were performed to evaluate the effects of depth, field size, distance from the field edge, collimator angle, and beam modi-fiers for common treatment protocols and modalities. A custom fetal lead shiel...

Article history: Received: 23 Dec 2011 Revised: 13 Jan 2012 Accepted: 24 Jan 2012

The objectives of this pilot study were to assess the findings of low-field MRI in symptomatic thumb base osteoarthritis (OA), to identify suitable MRI sequences with or without Gadolinium contrast, and to compare these findings with conventional radiographs scored by the Altman atlas and patient reported pain. Twelve patients with symptomatic thumb base osteoarthritis participated. We used a 0...

The present study was designed to comparatively evaluate the effect of G.T.R. with or without tetracycline root conditioning in the treatment of intrabony defects using a resorbable membrane. To achieve these aims, the following objectives were followed: Evaluation of pre surgical probing depths (PD) and it’s comparison post operatively. Comparison of the clinical attachment levels (CAL) pre su...

background: stem-cell technology has been advocated as a potentially curative option for treatment of both type 1 and type 2 diabetes. in the current study, we aimed to assess the effectiveness of allotransplantation of fetal liver-derived cells for treatment of patients with type 1 diabetes. methods: for the purpose of the current study, 72 patients with recently diagnosed type 1 dm were recru...

T wo proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies have obtained approval by the United States Food and Drug Administration: evolocumab (Amgen) and ali-rocumab (Sanofi/Regeneron). Per their package inserts, both are "indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (FH) or clinic...