McDonald/Kreitman tests performed on animal mtDNA consistently reveal significant deviations from strict neutrality in the direction of an excess number of polymorphic nonsynonymous sites, which is consistent with purifying selection acting on nonsynonymous sites. We show that under models of recurrent neutral and deleterious mutations, the mean age of segregating neutral mutations is greater t...

cardiovascular disease (cad) screening in asymptomatic patients with diabetes mellitus is controversial. an exercise stress test is a safe and effective initial testing for ischemic heart disease (ihd) screening. treadmill stress test is not the best screening method for a particular patient who is not able to exercise, abnormal electrocardiogram (ecg) or positive exercise treadmill test (ett) ...

The synthesis of aryl amides via the reactions of carboxylic acids and isocyanides in methanol was carried out in 78-95% yields under ultrasound irradiation. The method has wide applicability, and the protocol is mild, fast and efficient compared to the existing methods based on silent conditions.

Assessing silent reading fluency in classroom environments is challenging. This article reports on a method of assessing silent reading using underlining, an approach that solves many problems other silent reading fluency assessment measures face. This method computationally monitors readers’ silent reading fluency by the speed they underline words in a text. Traditional silent reading fluency ...

Climate has always been changing during the lifetime of the earth, and has appeared in the form of the ice age, hurricanes, severe and sudden temperature changes, precipitation and other climatic elements, and has dramatically influenced the environment, and in some cases has caused severe changes and even destructions. Some of the most important aspects of climate changes can be found in preci...

Environmental factors are being increasingly taken into account in the increasing development of urbanization and citizen residential requirements. Climate and climate conditions are among the environmental factors that have always influenced human welfare. Climate has always been incorporated in old urban structures in Iran and can be easily observed. Despite the importance of climate-related ...

BACKGROUND AND PURPOSE The prevalence of silent brain infarcts in healthy elderly people is high, and these lesions are associated with an increased risk of stroke. The incidence of silent brain infarcts is unknown. We investigated the incidence and cardiovascular risk factors for silent brain infarcts. METHODS The Rotterdam Scan Study is a prospective, population-based cohort study of 1077 p...