BACKGROUND Thelper1 (Th1) lymphocytes have been previously implicated in atherosclerotic plaque growth but their role in plaque vulnerability to rupture is less clear. We investigated whether T-bet knockout that prevents Th1 lymphocyte differentiation modulates classical (M1) macrophage activation or production of matrix degrading metalloproteinases (MMPs) and their tissue inhibitors, TIMPs. ...

Understanding the concept of viral plaque and the process of viral plaque formation is essential for navigating viral biology and grasping the foundations of key laboratory methods in virology. Plaque assays are utilized routinely in Microbiology and Virology teaching laboratories to quantify viruses and as a tool to introduce and/or reinforce the technique of serial dilutions (2). The hands-on...

abstract introduction:  this study was performed to compare the effects of low-dose interferon beta-1(cinnovex,30 mcg) and high-dose interferon beta-1(rebif,44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods and materials: this historical cohort study, which was performed in 2014 in sanandaj (western p...

Background—It has been reported that circulating endothelial progenitor cells (EPCs) home to and differentiate into endothelial cells after various kinds of arterial injury. By inference, EPCs are also proposed to be important in the most important arterial disease, atherosclerosis, but the evidence for this theory is not clear. In the present study, we assessed the contribution of circulating ...

BACKGROUND It has been reported that circulating endothelial progenitor cells (EPCs) home to and differentiate into endothelial cells after various kinds of arterial injury. By inference, EPCs are also proposed to be important in the most important arterial disease, atherosclerosis, but the evidence for this theory is not clear. In the present study, we assessed the contribution of circulating ...

background one of the most important causes of mortality in developed and developing countries is coronary artery disease. coronary artery disease (cad) may develop by deposition of lipid, fibrous or calcified debris on the surface of the coronary artery lumen. fibrous plaque and calcified plaque may cause substantial stenosis of coronary arteries leading to ischemia of heart muscle while lipid...

background: this study was performed to compare the effects of low dose interferon beta-1 (ifn-β-1) (cinnovex, 30 mcg) and high dose ifn-β-1 (rebif, 44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods: this historical cohort study, which was performed in 2014 in sanandaj (western part of iran). 43 ms pa...

background : the aim of this study was to detect fungi in atherosclerotic plaques and investigate their possible role in atherosclerosis. methods : coronary atherosclerotic plaques specimen were obtained from patients with atherosclerosis. direct exami-nation, culture, histopathology study, pcr and sequencing were performed to detect/identify the mycotic elements in the plaques. age, sex, smoki...

Psoriasis is a common genetic autoimmune disorder with global prevalence of 2–3%. The clear pathogenesis psoriasis not fully understood, but hyperproliferation and inflammation the epidermis marked infiltration immune cells have been indicated in such producing different types cytokines- interleukin. As new member IL-1 cytokine family, some research, IL-33 has linked showing high serum concentr...