نتایج جستجو برای: cisplatin toxicity

تعداد نتایج: 143067  

Journal: :Japanese journal of clinical oncology 2001
K Hotta I Sekine T Tamura M Sawada H Watanabe H Kusaba Y Akiyama A Inoue T Shimoyama H Nokihara Y Ueda N Yamamoto H Kunitoh Y Ohe T Kodama N Saijo

BACKGROUND A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a fixed dose of cisplatin every 3 weeks and to observe the response in Japanes...

Journal: :International journal of radiation oncology, biology, physics 2007
David K Gaffney Kathryn Winter Adam P Dicker Brigitte Miller Patricia J Eifel Janice Ryu Vilija Avizonis Mitch Fromm Kathryn Greven

PURPOSE To determine treatment-related acute toxicity rates in patients with locally advanced cervical cancer treated by oral celecoxib, i.v. cisplatin and 5-FU, and concurrent pelvic radiation therapy. METHODS AND MATERIALS Eligible patients on this RTOG Phase I-II study for advanced cervix cancer included FIGO Stage IIB-IVA or patients with FIGO Stage IB through IIA with biopsy proven pelvi...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 1999
J R Kroep G J Peters C J van Moorsel A Catik J B Vermorken H M Pinedo C J van Groeningen

PURPOSE To evaluate the tolerability of four alternating cisplatin-gemcitabine schedules. A secondary aim was to evaluate the clinical efficacy of this combination. PATIENTS AND METHODS Forty-one patients with advanced solid tumors received alternating sequences with a 4- and 24-hour interval of cisplatin and gemcitabine. Gemcitabine 800 mg/m2 was administered as a 30-min infusion on day 1, 8...

Journal: :International journal of radiation oncology, biology, physics 2013
Joseph M Herman Charles R Thomas

Much progress has been made over the past few decades in the diagnosis and management of cancer of the anal canal, such that organ preservation is possible in most patients who present without evidence of metastases (1, 2). Subsequent studies have focused on improving response rates and decreasing toxicity. Approaches include radiation dose escalation, integration of alternative chemotherapy re...

Journal: :Annals of palliative medicine 2021

BACKGROUND To evaluate the efficacy and toxicity of docetaxel, cisplatin, fluorouracil (TPF) regimen followed by intensity modulated radiotherapy (IMRT) on locally advanced nasopharyngeal carcinoma (NPC). METHODS A total 150 patients with NPC [American Joint Committee Cancer (AJCC) 2009 stage IIIa-IVb] received 2 or 3 cycles a TPF as induction chemotherapy. group 67 participants (TPF group) con...

F. Talebpour Amiri* S.J. Hosseinimehr Sh. Karimi

Background and objectives: Cisplatin (CP), a highly effective antineoplastic drug, causes testicular damage. Zataria multiflora Boiss. (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of ZM against cisplatin-induced testicular toxicity. Methods: Thirty-two adult male mice wer...

Journal: :Cancer research 2002
Daqing Li Brian Ronson Ming Guo Shixi Liu Jeffrey S Bishop David A Van Echo Bert W O'Malley

Cisplatin has been the most promising single chemotherapeutic agent usedagainst head and neck squamous cell cancer to date. However, dose-related toxicity has been one of the major limiting factors in cisplatin-based therapies, because high doses are required for obtaining a significant antitumor effect. To face the challenge of this limiting factor, a novel interleukin 2 (IL-2)-based combinati...

Journal: :Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012
Graciela Cristina Dos Santos Leonardo Meneghin Mendonça Gilmara Ausech Antonucci Antonio Cardozo Dos Santos Lusânia Maria Greggi Antunes Maria de Lourdes Pires Bianchi

Bixin is the main carotenoid found in annatto seeds (Bixa orellana L.) and is responsible for their reddish-orange color. The antioxidant properties of this compound are associated with its ability to scavenge free radicals, which may reduce damage and protect tissues against toxicity caused by anticancer drugs such as cisplatin. In this study, the genotoxicity and antigenotoxicity of bixin on ...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997
M K Kuhlmann G Burkhardt H Köhler

Cisplatin preferentially accumulates in cells of the S3 segment of the renal proximal tubule and is toxified intracellularly by hydration. The earliest manifestation of toxicity is inhibition of protein synthesis. GSH depletion is another important mechanism causing CP toxicity. Intracellular binding to SH groups leads to GSH depletion, resulting in lipid peroxidation and eventually mitochondri...

2002
Robin S. Goldstein Gilbert H. Mayor

Cisplatin is a cancer chemotherapeutic agent whose cl inical use is complicated by i ts dose related kidney toxicity. Since the histopathological profi le of cisplatin nephrotoxicity appears similar to that of other heavy metals, i t has been commonly presumed that cisplatin nephrotoxicity is related to the platinum moiety. However, the delayed time course and development of cisplatin nephrotox...

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