Platinum-organic Compounds, Syntheses, Reductive Elimination, Activation Parameters The Compounds cw-[Pt(PPh3)2(4-X-C6H4)2] [X = F, Cl, CF3, OCH3, N(CH3)2] and cis[Pt(PPh3)2(4-X-C6H4)(Y-C6H4)] [X = F/Y = 3 Cl, 4-C1, 3-CH30, 4 -CH 3 0; X = CF3/Y = 3-F, 4-F] have been synthesized and studied thermally with respect to the reductive elimination of disubstituted biphenyls. Activation parameters A H+...

Platinum(IV) am(m)ine complexes are of interest as potential anticancer pro-drugs, but there are few reports of their acid-base properties. We have studied the acid-base properties of three photoactivatable anticancer platinum(IV)-diazidodiam(m)ine complexes (cis,trans,cis-[Pt(IV)(N(3))(2)(OH)(2)(NH(3))(2)], trans,trans,trans-[Pt(IV)(N(3))(2)(OH)(2)(NH(3))(2)], and cis,trans-[Pt(IV)(N(3))(2)(OH...

The mixed nucleobases complexes cis-[L(2)Pt{1-MeTy(-H)}(1-MeCy,N(3))]NO(3) (L = PPh(3), ; PMePh(2), ), containing the N(3)-deprotonated 1-methylthymine (1-MeTy(-H)) and the neutral 1-methylcytosine (1-MeCy) have been prepared and characterised. The compounds were obtained by reacting the hydroxo complexes cis-[L(2)Pt(mu-OH)](2)(NO(3))(2) with 1-methylthymine (1-MeTy), followed by the addition o...

In the mononuclear title complex, [Pt(CH(3))Cl(C(25)H(23)N(2)P)], the N-benzyl-N-(diphenyl-phosphanylmeth-yl)pyridin-2-amine functions as a bidentate ligand with the pyridyl N atom and the phosphine P atom chelating the Pt(II) ion, forming a six-membered metallocycle. The Pt(II) atom adopts a square-planar coordination geometry with one methyl group and one chloride ligand bonding to the metal ...

In the mononuclear title complex, [Pt(C(7)H(7))(2)(C(8)H(12))], the Pt(II) ion exhibits a square-planar coordination geometry defined by two methyl-phenyl ligands and the mid-points of the two π-coordinated double bonds of cyclo-octa-1,5-diene. The two methyl-phenyl groups have a cis relationship with a C-Pt-C bond angle of 88.54 (18)° and a dihedral angle between the mean planes of the benzene...

A series of Pt(ii) complexes containing silole-based ligands with diphenylphosphino groups terminally bound to a conjugated organic linker unit coordinated to the silole ring in the 2- or 2,5-positions, 1,1-dimethyl-2-(5'-diphenylphosphino-2'-thienyl)-3,4-diphenylsilole (4), 1,1-dimethyl-2,5-bis(5'-diphenylphosphino-2'-thienyl)-3,4-diphenylsilole (5), and 1,1-dimethyl-2,5-bis(4'-diphenylphosphi...

Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass spectrometry (ICP-MS). Vitamin B12 (cyano-cob(iii)alamin) and aquo-cob(iii)alamin [Cbl-OH2](+), which differ in the β-axial ligands (CN(-) and H2O, respectively), were included as control samples. The results indicated that B12 derivativ...

The monofunctional platinum complex cis-[Pt(NH3)2Cl(Am)](+), also known as phenanthriplatin, where Am is the N-heterocyclic base phenanthridine, has promising anticancer activity. Unlike bifunctional compounds such as cisplatin, phenanthriplatin can form only one covalent bond to DNA. Another distinguishing feature is that phenanthriplatin is chiral. Rotation about the Pt-N bond of the phenanth...

Complexes of the tetrachoroplatinum(II) dianion with positively charged nuclear dyes were prepared in an effort to produce agents which gain ready access into the nucleus and become very cytotoxic at clinically relevant hyperthermia temperatures. Pt(Nile blue)2 and Pt(neutral red)2 are complexes of tetrachloroplatinum(II) with two closely related p-quinonediamine dyes. Pt(Nile blue)2 and Pt(neu...

Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.