Background: Portal hypertension in cirrhosis results from enhanced intrahepatic resistance to an augmented inflow. The former is partly due to an imbalance between intrahepatic vasoconstriction and vasodilatation. Enhanced endothelin-1 and decreased activity of hepatic constitutive endothelial nitric oxide synthase (NOS 3) was reported in carbon tetrachloride (CCl4) cirrhotic rat liver. Aims: T...

We assessed different systolic cardiac indices to detect left and right ventricular systolic dysfunction in cirrhotic patients before liver transplantation. Between 2010-2011, 81 consecutive individuals with confirmed hepatic cirrhosis who were a candidate for liver transplantation were enrolled in this study. A total of 32 age and sex matched healthy volunteers were also selected as the contro...

The only currently validated treatment for advanced hepatocellular carcinoma (HCC) is sorafenib. However, sorafenib has been mainly studied in patients with HCC developed in cirrhotic liver. Chemotherapy might be more suitable for patients with HCC in non-cirrhotic liver. We report the case of a young woman with fibrolamellar HCC in a non-cirrhotic liver, with histologically proven metastatic g...

Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by an abnormal and blunted response to physiologic, pathologic, or pharmacologic stress but normal to increased cardiac output and contractility at rest. As many as 50% of cirrhotic patients undergoing liver transplantation show signs of cardiac dysfunction, and 7% to 21% of deaths after orthotopic li...

Cirrhotic ascites, in which secondary hyperaldosteronism is a notable feature, is associated with impaired gastric secretion (Baddeley, 1968). Obstruction to hepatic venous outflow, which also induces secondary hyperaldosteronism and ascites (Orloff, Ross, Baddeley, Nutting, Spitz, Sloop, Neesby, and Halasz, 1964), depresses acid secretion from Heidenhain pouches in dogs with cirrhotic and non-...

conclusions these results revealed that cirrhosis produce prolonged qt interval and sour cherry extract has an ameliorating effect on qt prolongation probably via its antiarrhythmic property. results results were analyzed by using student t-test and one-way anova. p < 0.05 was considered as significant level. the qt interval was calculated using the bazettʼs formula and corrected qt (qtc) was o...

INTRODUCTION Cirrhosis secondary to HCV infection is expected to peak in the next decade, particularly in the HIV co-infected subgroup and has become a leading cause of morbidity among these individuals. Efforts must be done to estimate the risk of liver decompensation (LD) in the short term, in order to define the appropriate time for HCV treatment. MATERIALS AND METHODS Retrospective observ...

BACKGROUND/AIMS Cirrhotic patients are prone to various infectious diseases. However, it is still unknown if the occurrence of a brain abscess is associated with cirrhosis. The purpose of this study was to identify the relationship between the occurrence of a brain abscess and cirrhosis. MATERIALS AND METHODS The National Health Insurance Database, which is derived from the Taiwan National He...

BACKGROUND/AIMS The role of H. pylori in the pathogenesis of ulcer disease in cirrhotic patients is poorly defined. Therefore, we sought to investigate the prevalence of H. pylori infection and the occurrence of gastroduode-nal lesions in patients with liver cirrhosis. METHODS AND PATIENTS Seroprevalence of H. pylori was tested in 110 patients with liver cirrhosis and 44 asymptomatic patients...