BACKGROUND The long-term outcomes of patients with autoimmune hepatitis (AIH) given the immunosuppressive treatment are considered to be preferable. However, little is known about the response of AIH patients with cirrhosis to immunosuppressive treatment. We assessed the effects of immunosuppressive therapy in Chinese AIH patients with cirrhosis from a tertiary hospital. METHODS Patients with...

Non-alcoholic steatohepatitis has emerged as a major public health problem, and the burden of non-alcoholic cirrhosis is projected to increase by 64%-156% 2030. The threat aggravated fact that are currently no approved drugs for treatment steatohepatitis. In this paper, we review main challenges drug development in patients with cirrhosis, describe opportunities brought advances understanding c...

Background: Liver Cirrhosis is the end-stage for chronic liver disease. Repeated course of endoscopy recommended, as this intervention expensive and often poorly accepted by patients, there a need non-invasive methods to predicts progression portal hypertension well presence size esophageal varices. This study was aimed assess APRI Transient Elastography predicting variceal bleed in cirrhotic p...

conclusions several adverse effects are associated to anti-hcv drugs, hence appropriate skin care management and follow-up are very important. a careful anamnesis before the initiation of triple therapy is necessary to identify previous dermatological diseases that could increase skin adverse effects incidence. case presentation we report a case of a patient who discontinued telaprevir because ...

Hepatitis C virus is the main agent responsible for post-transfusion hepatitis. Progression to chronic hepatitis, cirrhosis and hepatocellular carcinoma is very common. The aim of this study was to evaluate the frequency, timing and factors related to progression of hepatitis C. One hundred seventy five patients with chronic post-transfusion hepatitis C were grouped in a cirrhosis group (n = 92...

The prevalence of cirrhosis has risen significantly over recent decades and is predicted to rise further. Widespread use non-invasive testing means increasingly diagnosed at an earlier stage. Despite this, there are significant variations in outcomes patients with across the UK, areas higher levels deprivation more likely die from their liver disease. This three-part best practice guidance aims...

OBJECTIVE The aim of this study is to evaluate the liver metastasis risk among colorectal cancer patients with liver cirrhosis. METHODS This was a nationwide population-based cohort study of 2973 newly diagnosed colorectal cancer patients with liver cirrhosis and 11 892 age-sex matched controls enrolled in Taiwan between 2000 and 2010. The cumulative risk by Kaplan-Meier method, hazard ratio ...

Hipertensi portal merupakan konsekuensi klinis dari sirosis hati. Angka kematian karena hipertensi masih tinggi di Indonesia. Pada kondisi kompensata munculnya yang signifikan secara (clinically significant hypertension/CSPH) dapat memprediksi kejadian dekompensasi dan penanda prognosis penyakit lebih buruk. Diagnosis CSPH dengan cara invasif ataupun non-invasif. Tata laksana pada diutamakan un...

Disorders of glucose metabolism, namely glucose intolerance and diabetes, are frequent in patients with chronic liver diseases. In patients with cirrhosis, diabetes can be either a classical type 2 diabetes mellitus or the so-called hepatogenous diabetes, i.e. a consequence of liver insufficiency and portal hypertension. This review article provides an overview of the possible pathophysiologica...

Background and purpose - There are limited data on risk factors for avascular necrosis of the hip, but cirrhosis has been proposed as a risk factor. We examined the association between cirrhosis and incidence of total hip arthroplasty for avascular necrosis. Methods - We used nationwide healthcare data to identify all Danish residents diagnosed with cirrhosis in 1994-2011, and matched them 1:5 ...