Medical management is the mainstay in the management of ocular surface disease, with surgical therapy being reserved only for the most severe forms of the condition. Ocular surface disease encompasses a wide range of conditions such as dry eye, limbal stem cell deficiency disorders, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Surgical management of these disorders has witnessed ...

Autoimmunity to type-WI collagen is characterized by autoantibodies predominantly of lgG class to the non-collagenous domain of type-WI collagen present in the anchoring fibrils which bind basement membrane lamina densa to the anchoring plaques in the dermis. This results in a sublami.na densa split with a blister formation. Type WI collagen autoim.munity is heterogenous in its clinical spectru...

Many studies have been trying to identify genetic markers for ophthalmological diseases, including, among others, the HLA (Human Leukocyte Antigens). Localized on the short arm of chromosome 6, the human leukocyte antigen system is well known for its capacity to confer susceptibility or resistance to different diseases. In view of its accentuated polymorphism, the strength and type of associati...

Background Ocular cicatricial pemphigoid (OCP) is a chronic, immune-mediated, fibrosing disease that can lead to blindness. The diagnosis clinical and/or based on the results of conjunctival biopsy. There are no studies have studied histopathological findings and risk sequelae in this entity. Objectives describe biopsies from patients with OCP identify characteristics may be associated greater ...

BACKGROUND Mucous membrane pemphigoid (MMP), also known as cicatricial pemphigoid, is a serious, autoimmune, blistering disorder that can result in blindness and other complications as a result of scarring of the mucous membranes. Effective treatment modalities are often toxic. Herein, we describe a novel therapeutic approach that is based on 2 reports in the literature of the successful use of...