Major depression is one of the leading causes of premature death and disability. Although available drugs are effective, they also have substantial limitations. Recent advances in our understanding of the fundamental links between chronobiology and major mood disorders, as well as the development of new drugs that target the circadian system, have led to a renewed focus on this area. In this re...

This contribution describes a new laboratory experience that improves medical students' learning of chronobiology by introducing them to basic chronobiology concepts as well as to methods and statistical analysis tools specific for circadian rhythms. We designed an autorhythmometry laboratory session where students simultaneously played the role of researchers and experimental subjects. During ...

The biopsychosocial model allows an evaluation of different parameters involved in chronic pain. There may, however, be simple non-iatrogenic strategies based on the physiology that can improve treatment outcome. Non-drug strategies as nutrition, neutraceuticals and acupuncture in addition to drugs take a special place in the management of critical situations were conservative treatment failed....

Major depression is one of the leading causes of premature death and disability. Although available drugs are effective, they also have substantial limitations. Recent advances in our understanding of the fundamental links between chronobiology and major mood disorders, as well as the development of new drugs that target the circadian system, have led to a renewed focus on this area. In this re...

Part of the research in this paper was supported by grants from the Swiss National Foundation START grant: 3130-054991 and 3100-055385.98. We thank Dr. Knoblauch for help in study coordination and data collection. We wish to thank Prof. Anna Wirz-Justice for her continuing support. Correspondence should be addressed to Christian Cajochen, Centre for Chronobiology, Psychiatric University Clinic,...

Willemijntje A. Hoogerwerf, Vahakn B. Shahinian, Germaine Cornélissen, Franz Halberg, Jonathon Bostwick, John Timm, Paul A. Bartell, and Vincent M. Cassone Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michi...

1 Contributed equally 5 2 Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, 6 Germany. 7 3 Chronophysiology Group, Medical Department I, University of Lübeck, Lübeck, Germany. 8 4 Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 9 University of Toronto, Toronto, Ontario, Canada. 10 5 Current address: Department of Psychiatry...

The circadian clock is a powerful endogenous timing system, which allows organisms to fine-tune their physiology and behaviour to the geophysical time. The interplay of a distinct set of core-clock genes and proteins generates oscillations in expression of output target genes which temporally regulate numerous molecular and cellular processes. The study of the circadian timing at the organismal...