Chronic ulcers represent a major health burden in our society. Despite many available therapies, a large number of ulcers do not heal. Protein based therapies fail in part due to proteolytic activity in the chronic wound bed. The aim of this in vitro study was to determine whether typical inflammatory cytokines and human salivary histatins remain stable when incubated with chronic wound extract...

The central portion of chronic wounds is often hypoxic and relatively hypothermic, representing a deficient energy supply of the tissue, which impedes wound healing or even makes it impossible. Water-filtered infrared-A (wIRA) is a special form of heat radiation with a high tissue penetration and a low thermal load to the skin surface. wIRA produces a therapeutically usable field of heat and in...

The lack of fundamental knowledge on the biological processes associated with wound healing represents a significant challenge. Understanding the biochemical changes that occur within a chronic wound could provide insights into the wound environment and enable more effective wound management. We report on the stability of wound fluid samples under various conditions and describe a high-throughp...

Significance: Natural, endogenous electric fields (EFs) and currents arise spontaneously after wounding of many tissues, especially epithelia, and are necessary for normal healing. This wound electrical activity is a long-lasting and regulated response. Enhancing or inhibiting this electrical activity increases or decreases wound healing, respectively. Cells that are responsible for wound closu...

W individuals of all ages (from neonates to elders) and all socioeconomic groups develop chronic wounds (i.e., a break or chronic ulcer of the skin and underlying tissue that does not respond to medical or surgical interventions). This is particularly true for people living with advanced/end-stage chronic illnesses associated with arterial or venous insufficiency/ edema (e.g., diabetes mellitus...

BACKGROUND Non-healing chronic wounds, such as venous leg ulcers, can be monitored non-invasively by using modern sensing devices and wireless technologies. The development of such a wireless diagnostic tool may improve chronic wound management by providing evidence on efficacy of treatments being provided. This paper presents a low-power portable telemetric system for wound condition sensing a...

BACKGROUND Current treatment modalities for chronic leg ulcers are time consuming, expensive, and only moderately successful. Recent data suggest that creating a subatmospheric pressure by vacuum-assisted closure (V.A.C., KCI Concepts, San Antonio, Texas) therapy supports the wound healing process. METHODS The efficacy of vacuum-assisted closure in the treatment of chronic leg ulcers was pros...

Wound management is to provide an appropriate environment for the wound its healing without breakdown of skin. It ongoing treatment process that includes size, severity, depth, and location wound. Carbon-based nanomaterials have greater potential chronic infections as compared conventional approaches. The physiochemical properties these nanostructured materials may enable clinicians develop mor...