Phenytoin (PHT), a drug in clinical use for over fifty years as an anticonvulsant, has heen reported to promote the healing of skin and soft tissue wounds, ulcers and second degree burns. We treated 19 patients with war-related missile wounds and 6 with chronic, non-healing (previously treated at least for.') months with antibiotics and betadine or acetic acid dressing) civilian ulcers wit...

phenytoin (pht), a drug in clinical use for over fifty years as an anticonvulsant, has heen reported to promote the healing of skin and soft tissue wounds, ulcers and second degree burns. we treated 19 patients with war-related missile wounds and 6 with chronic, non-healing (previously treated at least for.') months with antibiotics and betadine or acetic acid dressing) civilian ulcers wit...

Wound healing is a complex biological process involving various cells, mediators, and components of the extracellular matrix involved in processes coagulation, inflammation, angiogenesis, epithelialization, fibroplasia. described by four interrelated phases: hemostasis, proliferation remodeling. Each phases has its role at molecular tissue levels, if defect occurs chain one wound process, distu...

In healthy tissue, a wound initiates an inflammatory response characterized by the presence of a hematoma, infiltration of inflammatory cells into the wound and, eventually, wound healing. In pathological conditions like diabetes mellitus, wound healing is impaired by the presence of chronic nonresolving inflammation. p38 mitogen-activated protein kinase (MAPK) inhibitors have demonstrated anti...

Chronic non-healing wounds lead to considerable morbidity and mortality. Pleiotropic effects of high density lipoproteins (HDL) may beneficially affect wound healing. The objectives of this murine study were: (1) to investigate the hypothesis that hypercholesterolemia induces impaired wound healing and (2) to study the effect of topical HDL administration in a model of delayed wound healing. A ...

Non-healing wounds are a growing public health concern, and more than $25 billion per year in the US are spent caring for patients with chronic wounds. Many of these patients are referred to specialized wound centers, where hyperbaric oxygen therapy (HBO2T) has become a mainstay in healing wounds, especially diabetic foot ulcers (DFU). However, it is costly, with a typical course of therapy run...

Ultrasonic Patches In article number 2100785 by Xue Feng and co-workers, a flexible ultrasonic patch is designed fabricated for chronic wound treatment. While the applied to damaged area of wound, it makes conversion Rac1-GDP Rac1-GTP, which can accelerate healing wound. The soft, light completely conform treatment treat effectively.

Chronic wounds typically have excessive levels of matrix metalloproteinases (MMPs) and proinflammatory cytokines that impair healing. Reducing these detrimental proteins may be key to healing chronic wounds. Proprietary protease blends were formulated specifically to degrade excessive amounts of proinflammatory factors that could prevent wound healing. Applications of protease-containing wound ...

The treatment of chronic wounds remains problematic, despite new insight into the cellular and molecular basis of wound healing. Although the aetio-pathogenesis of chronic wounds is said to be multi-factorial, it is evident from literature that effective and adequate wound debridement has produced the most consistent effect in chronic wound treatment. There is a growing body of evidence that su...