when stretcher came to unit and i was put in my bed, nursing personnel of surgical ward said to me hello. i had seen their face from yesterday night when they were transferring patients from emergency ward to this unit.  in that time, i had the role of emergency ward assistant manager. today, i am a weak patient that even is unable for smallest movement. cause of my admission to hospital is mus...

Muscle dysfunction, characterized by a reductive remodeling of muscle fibers, is a common systemic manifestation in highly prevalent conditions such as chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), cancer cachexia, and critically ill patients. Skeletal muscle dysfunction and impaired muscle mass may predict morbidity and mortality in patients with chronic diseases, ...

The nitric oxide/soluble guanylyl cyclase (sGC) signal transduction pathway plays an important role in smooth muscle relaxation and phenotypic regulation. However, the transcriptional regulation of sGC gene expression is largely unknown. It has been shown that sGC expression increases in pulmonary arteries from chronic hypoxia-induced pulmonary hypertensive animals. Since the transcription fact...

Evidence has been accumulating that chronic inactivity leading to muscle disuse is unlikely to be the only explanation for the peripheral muscle dysfunction of chronic obstructive pulmonary disease (COPD) patients. Although a new concept of myopathy was recently proposed, the question of disuse and/or a form of myopathy is still being debated. This review proposes definitions for the terms used...

OBJECTIVE To determine whether stature recovery and paraspinal muscle activity can be altered in individuals with and without chronic low-back pain by assuming different unloading positions. DESIGN A case-control study considering the effects of unloading position on stature recovery in individuals with and without chronic low-back pain. BACKGROUND Stature recovery has been documented to be...