Chronic rhinosinusitis (CRS) rank second at chronic inflammatory diseases in industrialized countries and are an important public health concern. Diagnosis relies on a set of arguments including clinical signs, imaging, histopathologic and mycological analyses of sinus specimens, collected during nasal endoscopy. The sensitivity of fungal cultures is reported to be poor, even when direct examin...

INTRODUCTION The complicated etiology of chronic sinusitis with polyps and frequent allergy to mould is established. AIM We aimed to investigate the frequency of the IgE-dependent hypersensitivity in this group of patients and prove the need of surgery in allergic chronic rhinosinusitis patients. MATERIAL AND METHODS Forty-two patients (19 females, 23 males) aged 34-73 years (55 ±12.6 years...

We present a case of invasive pulmonary aspergillosis (IPA) in a previously healthy young woman who presented with what initially appeared to be an acute eosinophilic pneumonia. A second lung biopsy taken after treatment with steroids showed invasive Aspergillus with associated necrotizing granulomas, a pattern commonly found in chronic granulomatous disease (CGD). Both siblings, and by extrapo...

BACKGROUND Oral itraconazole is an antifungal that has been shown to be of benefit to patients with allergic bronchopulmonary aspergillus (ABPA). It is hypothesized that itraconazole may similarly benefit patients with allergic fungal sinusitis (AFS), a disease similar to ABPA. This study was designed to evaluate the therapeutic response of itraconazole in patients with refractory chronic funga...

Exophiala species are ubiquitous dematiaceous yeast-like fungi of the order Chaetothyriales that bear melanin-like pigment in their cell wall that is responsible for their dark color and is thought to be a major fungal virulence factor [1–3]. Among the agents of phaeohyphomycosis (cutaneous, subcutaneous, and invasive infections caused by dark-walled fungi), most human Exophiala infections are ...

A Non-Hodgkin’s lymphoma rapidly forms a deep ulcer and invades the sinuses, orbital wall, palate. It is important to detect treat early as it can, although rarely, be accompanied by rapid ulcerative destruction sepsis due necrosis. An 80-year-old female visited our hospital complaining of right nasal congestion facial edema. fungal ball in maxillary sinus defect anterior wall maxilla were obse...

BACKGROUND Chronic granulomatous disease (CGD) is associated with multiple and recurrent infections. In patients with CGD, invasive pulmonary infection with Aspergillus species remains the greatest cause of mortality and is typically insidious in onset. Acute fulminant presentations of fungal pneumonia are catastrophic. METHODS Case records, radiograph findings, and microbiologic examination ...

Rhinitis and sinusitis are among the most common medical conditions and are frequently associated. In Western societies an estimated 10% to 25% of the population have allergic rhinitis, with 30 to 60 million persons being affected annually in the United States. It is estimated that sinusitis affects 31 million patients annually in the United States. Both rhinitis and sinusitis can significantly...