We report a 72-year-old patient with chronic diarrhoea and histologic evidence of gastrointestinal histoplasmosis. He had no history of HIV or of taking immunosuppressive drugs. The patient was found to be a carrier of Human T-lymphotropic virus-1, a condition associated with inflammatory, lymphoproliferative, and opportunistic infectious diseases. To our knowledge, there are only three previou...

We report the case of a male chronic hepatitis B virus (HBV) carrier with HLA-B27 spondyloarthrititis who developed fulminant hepatitis after discontinuation of methotrexate (MTX). Full recovery after therapy with lamivudine and adefovir allowed treatment with adalimumab which was well tolerated. Reactivation of hepatitis B after MTX withdrawal is a very rare complication, which can also occur ...

Atypical haemolytic uraemic syndrome (aHUS) is a rare, life-threatening, chronic, genetic disease due to uncontrolled alternative pathway complement activation. In this report, we discuss the case of a heterozygous carrier of a mutation on both factor H and membrane cofactor protein, who persistently presents haemolytic anaemia without need for blood transfusions, normal platelet count, normal ...

Cytochrome b deficiency in the peripheral granulocytes of two male patients with chronic granulomatous disease was demonstrated by an immunocytochemical assay using a monoclonal antibody, 7D5, against human neutrophil cytochrome b. A mosaic of cytochrome b positive and negative neutrophils, indicating a carrier state in an X-linked trait, was found in the mother of patient 1 but not in the moth...

this study determines the value of linkage analysis using six rflp markers for carrier detection and prenatal diagnosis in familial dmd/bmd cases and their family members for the first time in the iranian population. we studied the dystrophin gene in 33 unrelated patients with clinical diagnosis of dmd or bmd. subsequently, we determined the rate of heterozygosity for six intragenic rflp marker...

Whilst the needs of individuals with sickle cell disorder (SCD) may be apparent, individuals with sickle cell trait (SCT) are generally reassured that their health will not be affected by their carrier status. Renal failure is a recognized complication of SCD; however, little is known concerning the relationship between SCT and the development of chronic kidney disease (CKD). In this short arti...

The part the diphtheria carrier plays in the production of epidemics has only lately been investigated, and it has been found that the infective agent has remained almost indefinitely in the nasal passages, or in otorrhceal discharges, in spite of all endeavours to disinfect. Upon these chronic infections the use of antitoxin seems to have little or no effect. On the other hand, immunity to the...

INTRODUCTION Typhoid fever is the most common illness caused by Salmonella typhi (S. typhi).(1) S. typhi bacteriuria can be seen following a recent episode of typhoid fever, or in chronic carrier state involving the urinary system, especially with local abnormalities of urinary tract.(2) However, S. typhi bacteriuria with renal stone disease has rarely been reported.(2) We presented a rare case...

Dr. Diogo Fraxino de Almeida – Avenida Independência 258/405 87015-020 Maringá PR Brasil. E-mail: [email protected] Asymptomatic hyperCKemia can be a clinical challenge for physicians, although its long term prognosis seems benign. The causes usually include heavy exercise practice, muscle injury, drug-induced myopathy, chronic alcoholism, hypothyroidism, clinically silent myopathies, an...