In a previous study of lung cancer, we showed that bleomycin, a radiomimetic agent, induced breaks preferentially on chromosomes 4 and 5. The molecular cytogenetic study reported here, using chromosome painting and G banding, was designed to assess whether the chromatid breaks induced by bleomycin could survive as chromosome-type aberrations after treated lymphocyte populations were allowed to ...

Immunoglobulin (Ig) A deficiency has long been recognized in patients with chromosome 18 abnormalities. We present the case of a young girl in whom a chromosome 18p deletion syndrome (46,XX,del[18][p11.1]) was associated not only with IgA deficiency, but also with an inability to make antibody to the unconjugated pneumococcal polysaccharide vaccine, Pneumovax II, indicating a concomitant specif...

Chromosome analyses were performed by a direct method on bone marrow cells of 147 patients with acute leukemia and preleukemia; in 53 chromosomally abnormal cell lines were found. Chromosome abnormalities due to structural alterations were observed in 48% of the aneuploid patients. Using the ASG banding technique, the exact identification of the abnormal chromosomes was successfully made in 22 ...

The article describes the cytogenetic parameters of seed progeny Pinus sylvestris plus trees growing in Petrozavodsk orchard first order. P. normal from natural pine phytocenosis Pryazha region (Karelia) were taken as a control. following indicators considered: relative DNA content, number chromosomes, frequency and types mitosis pathologies at metaphase, anaphase telophase stages (in % total d...

Among the hematologic malignancies, the clinical and biologic significance of chromosome abnormalities have been most extensively studied in the acute leukemias and chronic myelogenous leukemia (CML). Clonal chromosome abnormalities are now identified in essentially all cases of CML and in most cases of acute nonlymphoblastic leukemia (ANLL) and acute lymphoblastic leukemia (ALL). In the acute ...