Familial hypercholesterolemia (FH), known to be as the most important cause of severe hypercholesterolemia, is a genetic disease characterized by elevated LDL-Cholesterol (LDL-C), mainly caused by an autosomal dominant condition due to mutations in the LDLR gene that normally encodes the LDL receptor protein, leading to its decreased function and decreased LDL cholesterol clearance from the blo...

OBJECTIVE In patients with acute myocardial infarctions (MIs), cholesterol levels are no longer valid after 24 h from presentation because acute MI causes a rapid decline in serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. The objective of this study was to evaluate the effect of acute MI on the total cholesterol/HDL c...

A B S TRA CT The transfer of normal human fibroblasts from medium containing whole serum to medium devoid of lipoproteins produced a 90% decrease in the cellular content of cholesteryl esters and a 30% decrease in the free cholesterol content. When these lipoproteindeprived cells were subsequently incubated with human low density lipoprotein (LDL), there was a 7-fold increase in the cellular co...

INTRODUCTION High low-density lipoproteins (LDL) cholesterol is one of the major risk factors for cardiovascular disease. In recent years, some evidence has been presented that periodontitis, an infectious inflammatory condition of the periodontium, is associated with an increased risk of cardiovascular disease. To further elucidate this association, we have studied the levels of LDL cholestero...

PRINCIPLES Small dense LDLs have been found to be associated with type 2 diabetes (T2DM). This association has been observed in the context of decreased HDL cholesterol and increased triglycerides. METHODS In the present study the relationship between LDL particle size and insulin sensitivity was assessed in 46 patients with T2DM (mean age 60 (11) years, HbA1c 7.6 (0.8) %). 75 g oral glucose ...

The objectives of this analysis are to re-examine the foundational studies of the in vivo metabolism of plasma LDL (low-density lipoprotein) particles in humans and, based on them, to reconstruct our understanding of the governance of the concentration of plasma LDL and the maintenance of cholesterol homoeostasis in the hepatocyte. We believe that regulation of cholesterol homoeostasis within t...

BACKGROUND Low plasma levels of low-density lipoprotein (LDL) cholesterol are associated with an increased risk of cancer, but whether this association is causal is unclear. METHODS We studied 10 613 participants in the Copenhagen City Heart Study (CCHS) and 59 566 participants in the Copenhagen General Population Study, 6816 of whom had developed cancer by May 2009. Individuals were genotype...

Apolipoprotein (apo) E phenotype is an important genetic determinant of plasma low-density lipoprotein (LDL) cholesterol and apo B levels. We have determined apo E phenotype by isoelectric focusing and plasma lipid, lipoprotein cholesterol, apo A-I, apo B, and lipoprotein(a) levels, as well as LDL particle size, in 2258 men and women participating in the Framingham Offspring Study. Apo E phenot...

Studies were carried out on cholesterol metabolism in 11 nonobese patients and 16 obese patients with hypothyroidism and 13 with hyperthyroidism. The patients underwent several investigations under metabolic ward conditions. Hypothyroid patients usually had an increase in low density lipoprotein (LDL)-cholesterol. Several mechanisms may have combined to cause a high LDL. For instance, the obese...

We examined the effects of dietary cholesterol (less than 0.01 and 1.7 mg/Kcal) and type of fat (saturated, coconut oil; polysaturated, corn oil) on very low density plus low density lipoprotein (VLDL + LDL) and high density lipoprotein (HDL) cholesterol in 24 young baboons (12 male, 12 female) Paplo sp.) in a crossover design experiment. The oils contributed 40% of calories. Total serum choles...