نتایج جستجو برای: cho s

تعداد نتایج: 722353  

ژورنال: :مجله دانشکده پزشکی اصفهان 0
زهرا بزی گروه علوم تشریحی و بیولوژی ملکولی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران حسن کربکندی استادیار، گروه ژنتیک و بیولوژی ملکولی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران بتول هاشمی بنی استادیار، گروه علوم تشریحی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران زهره حجتی گروه زیست شناسی، دانشکده علوم، دانشگاه اصفهان امین مرادی حسن آباد گروه علوم تشریحی و بیولوژی ملکولی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران محمدرضا مراثی دانشیار، گروه آمار و اپیدمیولوژی، دانشکده ی بهداشت، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

مقدمه: بهینه سازی تولید اینترفرون بتا در سلول های cho (chinese hamster ovary) به عنوان یک میزبان بیانی که قادر به تولید پروتئین دارویی با کیفیت بالا می باشد، جهت کاهش قیمت و سرعت تولید این پروتئین نوترکیب دارویی از اهمیت زیادی برخوردار است. هدف این مطالعه، بررسی تأثیر پایداری mrna به واسطه ی ایجاد یک تغییر در اولویت کدونی در ناحیه ی ناپایدارکننده ی انتهای پروتئین اینترفرون بتا (crid یا coding r...

2008
S. S. Dragomir Yeol Je Cho

Correspondence should be addressed to S. S. Dragomir, [email protected] Received 27 May 2008; Accepted 4 August 2008 Recommended by Yeol Je Cho Some inequalities of the Grüss type for the numerical radius of bounded linear operators in Hilbert spaces are established. Copyright q 2008 S. S. Dragomir. This is an open access article distributed under the Creative Commons Attribution License...

2013
A. Fujisawa K. Itoh A. Shimizu H. Nakano S. Ohshima H. Iguchi K. Matsuoka S. Okamura T. Minami Y. Yoshimura K. Nagaoka K. Ida K. Toi C. Takahashi M. Kojima S. Nishimura M. Isobe C. Suzuki T. Akiyama T. Ido Y. Nagashima S.-I. Itoh P. H. Diamond

plasmaa... A. Fujisawa, K. Itoh, A. Shimizu, H. Nakano, S. Ohshima, H. Iguchi, K. Matsuoka, S. Okamura, T. Minami, Y. Yoshimura, K. Nagaoka, K. Ida, K. Toi, C. Takahashi, M. Kojima, S. Nishimura, M. Isobe, C. Suzuki, T. Akiyama, T. Ido, Y. Nagashima, S.-I. Itoh, and P. H. Diamond National Institute for Fusion Science, Oroshi-cho, Toki-shi, 509-52 Japan RIAM, Kyushu University, Kasuga 816-8580 J...

Journal: :Bioengineered 2012
Jong Youn Baik Clifford L Wang Bo Yang Robert J Linhardt Susan Sharfstein

Heparin is the most widely used pharmaceutical to control blood coagulation in modern medicine. A health crisis that took place in 2008 led to a demand for production of heparin from non-animal sources. Since Chinese hamster ovary (CHO) cells are capable of producing heparan sulfate (HS), a related polysaccharide naturally, and heparin and HS share the same biosynthetic pathway, we hypothesized...

Journal: :Journal of lipid research 2004
Ryan J Perry Neale D Ridgway

The cytotoxic effects of several chemotherapeutic drugs have been linked to elevated de novo ceramide biosynthesis. However, the relationship between the intracellular site(s) of ceramide accumulation and cytotoxicity is poorly understood. Here we examined the relationship between the site of ceramide deposition and inhibition of protein translation and induction of apoptosis by the antitumor/a...

2016
Andrew C. D’Lugos Nicholas D. Luden Justin M. Faller Jeremy D. Akers Alec I. McKenzie Michael J. Saunders

The effects of protein supplementation on cycling performance, skeletal muscle function, and heart rate responses to exercise were examined following intensified (ICT) and reduced-volume training (RVT). Seven cyclists performed consecutive periods of normal training (NT), ICT (10 days; average training duration 220% of NT), and RVT (10 days; training duration 66% of NT). In a crossover design, ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2012
Agnès Poirier Sara Belli Christoph Funk Michael B Otteneder Renée Portmann Katja Heinig Eric Prinssen Stanley E Lazic Craig R Rayner Gerhard Hoffmann Thomas Singer David E Smith Franz Schuler

It was reported that oseltamivir (Tamiflu) absorption was mediated by human peptide transporter (hPEPT) 1. Understanding the exact mechanism(s) of absorption is important in the context of drug-drug and diet-drug interactions. Hence, we investigated the mechanism governing the intestinal absorption of oseltamivir and its active metabolite (oseltamivir carboxylate) in wild-type [Chinese hamster ...

Journal: :The Plant cell 2002
Zhonglin Mou Xiaoqun Wang Zhiming Fu Ya Dai Chang Han Jian Ouyang Fang Bao Yuxin Hu Jiayang Li

S-Adenosyl-L-methionine:phosphoethanolamine N-methyltransferase (PEAMT; EC 2.1.1.103) catalyzes the key step in choline (Cho) biosynthesis, the N-methylation of phosphoethanolamine. Cho is a vital precursor of the membrane phospholipid phosphatidylcholine, which accounts for 40 to 60% of lipids in nonplastid plant membranes. Certain plants use Cho to produce the osmoprotectant glycine betaine, ...

Journal: :The Biochemical journal 2003
Kwang Ning Chang Te Chang Lee Ming F Tam Yi Chin Chen Li Wen Lee Shin Ying Lee Pei Jung Lin Rong Nan Huang

In this study, we report the identification of two arsenic-binding proteins from Chinese hamster ovary (CHO) cells. The crude extract derived from CHO and SA7 (arsenic-resistant CHO cells) was applied to a phenylarsine oxide-agarose affinity column, and after extensive washing, the absorbed proteins were eluted with buffers containing 20 mM 2-mercaptoethanol (2-ME) or dithiothreitol (DTT). Thre...

Journal: :Cancer research 1999
Y Cai M H Wu S M Ludeman D J Grdina M E Dolan

Cyclophosphamide is used to treat a wide range of human malignancies. However, it is also a known carcinogen associated with induction of therapy-related leukemia and bladder cancer. The DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT), protects cells from the toxic and mutagenic effects of O6-alkylating agents. We report here the contribution of AGT in protecting against the toxi...

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