The present study was undertaken to evaluate the possible protective effect of thymoquinone on chlorpromazine induced catalepsy, locomotor activity and cerebral oxidative stress in rats. The rats were divided into four groups, each group containing eight animals. The animals were evaluated after repeated administration of chlorpromazine (CPZ) 30 min before the administration of thymoquinone (TQ...

We describe a gas-chromatographic method for measuring chiorpromazine and its metabolites chiorpromazine sulfoxide, mono-N-desmethylchlorpromazine, and di-Ndesmethylchlorpromazine at therapeutic concentrations in human serum, with use of a nitrogen detector. The compounds are extracted from serum at pH 10.5 into hexane/isoamyl alcohol, re-extracted into dilute HCI, and then extracted into hexan...

UNLABELLED Through univalent oxidation chlorpromazine forms a colored and relatively stable radical cation with maximum absorbance at 525 nm, considered a redox mediator in a number of b iochemical reactions. AIM To develop a spectrometric method for the determination of total antioxidant activity based on the reaction of chlorpromazine radical capture by ascorbic acid (standard antioxidant)....

The issue of antipsychotics in psychiatry constituted a revolution at the time. The firsts, starting with chlorpromazine represent the conventional antipsychotics, in the last decades there was a new generation of antipsychotics, atypical, which improved the results in treating psychoses. Because, as any drug, it may have adverse effects we aimed an experimental study on rats to observe the tox...

This brief review frames the historical context surrounding antipsychotic medication for patients in nursing homes and other long-term care settings. The information is meant to describe, concisely, the evidence for and against the use of antipsychotic treatment. Every patient’s experience is distinctive, and each treatmentdecision has potential benefits and risks. The first antipsychotic medic...

Purpose: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of Celastrus paniculatus (C- paniculatus) seed extract on seizure severity and cognitive deficit following Pentylenetetrazole (PTZ) -induced chemical kindling model. Methods: PTZ kindling model was developed by daily administration of sub-convulsive dose of PTZ 30 mg/kg for...