Background. Pseudomonas aeruginosa is a causative agent of nosocomial infections. Chloramphenicol broad-spectrum, inexpensive, and common antibiotic. MexAB-OprM secretory pump that causes the innate resistance this bacterium. This study aimed to evaluate expression MexA gene under treatment copper nanoparticles chloramphenicol. Methods. In study, 49 samples were collected from 11 laboratories i...

Sir, An editorial in the British Medical Journal (BMJ)1 on the use of chloramphenicol eye drops suggested that the risks of topical chloramphenicol were sufficient to warrant practitioners to prescribe an alternative, such as Framycetin or Fucidic Acid. We sent a postal questionnaire to 664 general practitioners (GPs) in the areas of Leeds, Guildford, and Cambridge to ascertain the influence th...

Chloramphenicol can inhibit protein synthesis in mammalian cell-free systems as effectively as it inhibits protein synthesis in analogous microbial systems. Significant inhibition in mammalian systems was obtained only when protein synthesis was stimulated by the addition of template RNA to the system, there being comparatively little inhibition of protein synthesis by ribosomes in the absence ...

Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injections of the combination of busulfan and chloramphenicol developed lymphomas in ...

Children with cystic fibrosis are commonly colonized with multi-resistant bacteria. In such patients, infectious exacerbation may require salvage therapy with uncommonly used antimicrobials, including chloramphenicol. Chloramphenicol is rarely used nowadays because of the associated severe adverse events. We describe the case of a 15-year-old female with terminal cystic fibrosis who required in...